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TranscriptomicsR-loops are marks for histone H3 Ser10 phosphorylation and chromatin compaction
R-loops are transcription by-products that may constitute a threat to genome integrity. In addition to specific enzymes to remove them, eukaryotes rely on a number of mRNP biogenesis factors such as the THO complex, to prevent co-transcriptional R-loop formation. We show in Saccharomyces cerevisiae ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-11-13 | E-GEOD-46627 | biostudies-arrayexpress
GenomicsR-loops induce repressive chromatin marks over mammalian gene terminators
The formation of R-loops is a natural consequence of the transcription process, caused by invasion of the DNA duplex by nascent transcripts. These structures have been considered rare transcriptional by-products with potential harmful effects on genome integrity, due to the fragility of the displace...
ORGANISM(S): Homo sapiens 
2014-09-29 | E-GEOD-59878 | biostudies-arrayexpress
ProteomicsNAT10-dependent N4-acetylcytidine (ac4C) reprograms R-loops and promotes cancer stem cell growth
R-loop remodeling dynamically regulates chromatin states and gene expression; however, its exploitation by cancer to sustain self-renewal and malignancy remains poorly understood. Here, we found that glioblastoma (GBM) stem cells (GSCs) display highly active R-loops compared to differentiated tumor ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-10 | PXD077002 | Pride
Ac4c Cancer stem cell Nat10 Glioblastoma R-loop remodeling Glioblastoma stem cell 
ProteomicsIncrease in harmful R-loops associates with different alterations in mRNP composition
Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insights into the cellular mechanisms that prevent genome instability. Here, we identify three RNA-binding proteins, Rie1, Rim4 and She2, whose stoichiometry is importa...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2025-06-13 | PXD057248 | Pride
R-loops Tho complex Rna-binding proteins Messenger ribonucleoparticle 
GenomicsR-loops Function as a Balance during Somatic Cell Reprogramming
R-loops Function as a Balance during Somatic Cell Reprogramming
PRJNA517073 | ENA
ProteomicsNpl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence
Telomere shortening rates must be regulated to prevent premature replicative senescence. TERRA R-loops become stabilized at critically short telomeres to promote their elongation through homology-directed repair (HDR), thereby counteracting senescence onset. Using a non-bias proteomic approach to id...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-01-31 | PXD016772 | Pride
Lc-ms/ms  telomere  pulldown 
GenomicsLipid overload-induced R Loops formed by m6A-modified circTACC3
Lipid overload-induced R Loops formed by m6A-modified circTACC3
PRJNA1136959 | ENA
GenomicsADNP suppresses R-loops at its binding sites
ADNP suppresses R-loops at its binding sites
PRJNA719393 | ENA
GenomicsThe extruded non-template strand determines the architecture of R-loops
The extruded non-template strand determines the architecture of R-loops
PRJNA533230 | ENA
GenomicsCUT&Tag of R-loops in Ube2t knockdown P19 cells
CUT&Tag of R-loops in Ube2t knockdown P19 cells
PRJNA873920 | ENA
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