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TranscriptomicsAdipose Rab10 Knockout Causes Insulin Resistance through Impaired Glucose Uptake
Insulin action in adipocytes affects whole-body insulin sensitivity. Studies of adipose-specific Glut4 knockout mice have established that adipose Glut4 contributes to the control of systemic glucose homeostasis. Presumably, this reflects a role for Glut4-mediated glucose transport in the regulation...
ORGANISM(S): Mus musculus 
2016-06-30 | E-GEOD-70123 | biostudies-arrayexpress
ProteomicsAccurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson’s disease
Pathogenic mutations in the Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson’s disease (PD). They increase its activity, resulting in augmented Rab10-Thr73 phosphorylation and conversely, LRRK2 inhibition decreases pRab10 levels. Currently, there is no assay to qua...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD019814 | Pride
Phosphorylation stoichiometry Targeted mass spectrometry Parkinson’s disease 
ProteomicsAccurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson’s disease
Pathogenic mutations in the Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson’s disease (PD). They increase its activity, resulting in augmented Rab10-Thr73 phosphorylation and conversely, LRRK2 inhibition decreases pRab10 levels. Monitoring pRab10 can thus serve as...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD015219 | Pride
Parkinson's disease Phosphoproteomics 
ProteomicsPull down of Rab10 interactors in Raw264.7 cells
The goal of this project is to identify Rab10 interactors (in presence of GTP/GDP) in Raw264.7 macrophage cells.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD019723 | Pride
Apms Lcms 
ProteomicsRab10-CAV1 mediated intraluminal vesicles transport to migrasomes
Migrasomes, vesicular organelles generated on the retraction fibers of migrating cells, play a crucial role in migracytosis, mediating intercellular communication. The content cargoes determine the functional specificity of migrasomes. Migrasomes harbor numerous intraluminal vesicles, a pivotal comp...
ORGANISM(S): Mus Musculus 
2024-05-23 | PXD046146 |
TranscriptomicsAdipose Rab10 Knockout Causes Insulin Resistance through Impaired Glucose Uptake
Insulin action in adipocytes affects whole-body insulin sensitivity. Studies of adipose-specific Glut4 knockout mice have established that adipose Glut4 contributes to the control of systemic glucose homeostasis. Presumably, this reflects a role for Glut4-mediated glucose transport in the regulation...
ORGANISM(S): Mus musculus 
2016-06-30 | GSE70123 | GEO
ProteomicsR1441G but not G201S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils
Gain-of kinase function variants in LRRK2 (leucine-rich repeat kinase 2) cause Parkinson’s disease (PD), albeit with incomplete and age-dependent penetrance, offering the prospect of disease-modifying treatment strategies via LRRK2 kinase inhibition. LRRK2 phosphorylates a subgroup of RabGTPases inc...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024898 | Pride
Parkinsosn's disease Prm Lrrk2 Rab-gtpase 
UnknownCellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.
Not available
S-EPMC10726543 | biostudies-literature
UnknownRab10 GTPase regulates ER dynamics and morphology.
Not available
S-EPMC3582403 | biostudies-literature
UnknownElevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease.
Not available
S-EPMC9308673 | biostudies-literature
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