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GenomicsA histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme
The histone variant H2A.Z plays key roles in gene expression, DNA repair, and centromere function. H2A.Z deposition is controlled by SWR-C chromatin remodeling enzymes that catalyze the nucleosomal exchange of canonical H2A with H2A.Z. Here we report that acetylation of histone H3 lysine 56 (H3-K56A...
ORGANISM(S): Saccharomyces cerevisiae W303 
2013-04-15 | E-GEOD-43935 | biostudies-arrayexpress
GenomicsPatterns and mechanisms of ancestral histone protein inheritance in budding yeast
It is widely believed that chromatin, the nucleoprotein packaging state of eukaryotic genomes, can carry epigenetic information to propagate gene expression patterns in replicating cells. However, inheritance of genomic packaging status is subject to mechanistic challenges that do not confront the i...
ORGANISM(S): Saccharomyces cerevisiae 
2011-10-06 | E-GEOD-28269 | biostudies-arrayexpress
TranscriptomicsReplication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast
Histone modifications affect DNA-templated processes ranging from transcription to genomic replication. In this study, we examine the cell cycle dynamics of the trimethylated form of histone H3 lysine 4 (H3K4me3), a mark of active chromatin that is viewed as â??long-livedâ?? [1], and that is involve...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-GEOD-14565 | biostudies-arrayexpress
TranscriptomicsFeedback control of Set1 protein levels is important for proper H3K4 methylation patterns
Methylation of histone H3 lysine 4 by the Set1 subunit of COMPASS correlates withactive transcription. Here we show that Set1 levels are regulated by protein degradation in response to multiple signals. Set1 levels are greatly reduced when COMPASS recruitment to genes, H3K4 methylation, or transcrip...
ORGANISM(S): Saccharomyces cerevisiae 
2014-02-28 | E-GEOD-55082 | biostudies-arrayexpress
GenomicsDynamics of chromatin maturation after genome replication
Replication of the eukaryotic genome occurs in the context of chromatin, a nucleoprotein packaging state consisting of repeating nucleosomes. Chromatin is commonly thought to carry epigenetic information from one generation to the next, although it is unclear how such information survives the disrup...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-25 | E-GEOD-74090 | biostudies-arrayexpress
TranscriptomicsDynamics of nucleosome positioning maturation following genomic replication
Replication of the eukaryotic genome occurs in the context of chromatin, a nucleoprotein packaging state consisting of repeating nucleosomes. Chromatin is commonly thought to carry epigenetic information from one generation to the next, although it is unclear how such information survives the disrup...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-25 | E-GEOD-79384 | biostudies-arrayexpress
TranscriptomicsA Key Role for Chd1 in Histone H3 Dynamics at the 3' Ends of Long Genes in Yeast (H3K4me3 or H3K36me3 to input)
Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency. Here, we examine roles of Chd1 in replication- independent dynamics of histone H3 in yeast. Using genome-wide ChIP on chip analysis, we find tha...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-07 | E-GEOD-38492 | biostudies-arrayexpress
TranscriptomicsA Key Role for Chd1 in Histone H3 Dynamics at the 3' Ends of Long Genes in Yeast (Rpb3 to input)
Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency. Here, we examine roles of Chd1 in replication- independent dynamics of histone H3 in yeast. Using genome-wide ChIP on chip analysis, we find tha...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-07 | E-GEOD-38493 | biostudies-arrayexpress
TranscriptomicsA Key Role for Chd1 in Histone H3 Dynamics at the 3' Ends of Long Genes in Yeast (gene expression)
Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency. Here, we examine roles of Chd1 in replication- independent dynamics of histone H3 in yeast. Using genome-wide ChIP on chip analysis, we find tha...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-07 | E-GEOD-38496 | biostudies-arrayexpress
TranscriptomicsA Key Role for Chd1 in Histone H3 Dynamics at the 3' Ends of Long Genes in Yeast (Flag-tagged histone H3 to total histone H3)
Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency. Here, we examine roles of Chd1 in replication- independent dynamics of histone H3 in yeast. Using genome-wide ChIP on chip analysis, we find tha...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-07 | E-GEOD-38491 | biostudies-arrayexpress
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