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ProteomicsLepR deficiency, MEFs and iPSCs, LC-MS/MS
Leptin receptors (Lepr) are expressed by various types of stem cells including mesenchymal stem cells, hematopoietic stem cells, embryonic stem cells, and induced pluripotent stem cells. Leptin/lepr signaling is also a central regulator of metabolism. However, the role of Lepr in pluripotency, metab...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020959 | Pride
Mouse Stem cells 
ProteomicsLC-MSMS study of hiPSC-derived β-like cells in different 3D Eevironments
In this project hiPSC-derived β-like cells were studied in two different 3D enviromnets; size-adjusted cell aggregates (using Aggrewell™ plates) and inside alginate capsules. The hiPSC derived from a patient with maturity-onset diabetes of the young 1 (MODY1), which is a monogenic diabetes form, cau...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD025054 | Pride
Nf4a Cell aggregates Tmt quantification Β-cell differentiation Global proteomics Crispr/cas9 Mody1 Hipsc Alginate encapsulation 
ProteomicsDynamic proteome profiling of human induced pluripotent stem cell-derived pancreatic progenitors
Quantitative description of proteome dynamics during in vitro differentiation of hiPSCs towards pancreatic progenitor cells, providing time-specific protein signatures.
ORGANISM(S): Homo sapiens (Human) 
2021-08-30 | PXD003338 | Pride
And mass spectrometry Human induced pluripotent stem cells Proteomics Pancreatic progenitors Differentiation Time course Quantitative dynamics 
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