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ProteomicsEstablishment and characterization of a tumoroid biobank derived from dog patients’ mammary tumors for translational research
Breast cancer is the most frequent cancer among women causing the greatest number of cancer-related deaths. Cancer heterogeneity is a main obstacle to therapies. Around 96% of the drugs fail from discovery to the clinical trial phase probably because of the current unreliable preclinical models. New...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2023-03-11 | PXD031440 | Pride
Dog patients Drug screening Breast cancer Tumoroid Biobank 
ProteomicsA co-culture system of macrophages with breast cancer tumoroids to study cell interactions and therapeutic responses
3D tumoroids have revolutionized in vitro/ex vivo cancer biology by recapitulating the complex diversity of tumors. While tumoroid provide new insights into cancer development and treatment response, several limitations remain. The tumor microenvironment, especially the immune system, strongly influ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD052016 | Pride
Breast cancer Microscopy Tumoroids Macrophages Mass spectrometry imaging Drug response 
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