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TranscriptomicsTranscription profiling of brown adipose tissue in a glycerol kinase (Gyk) knockout mouse model to define GyKs role in insulin resistance
Glycerol kinase (GK) is at the interface of fat and carbohydrate metabolism and has been implicated in insulin resistance and type 2 diabetes mellitus (T2DM). To define GK's role in insulin resistance, we examined gene expression in brown adipose tissue in a glycerol kinase (Gyk) knockout (KO) mouse...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4656 | biostudies-arrayexpress
TranscriptomicsWeighted Gene Coexpression Network Analysis Identifies Biomarkers in Glycerol Kinase Deficient Mice
Symptomatic glycerol kinase deficiency (GKD) is associated with episodic metabolic and central nervous system deterioration. We report here the first application of Weighted Gene Co-Expression Network Analysis (WGCNA) to investigate a knockout (KO) murine model of a human genetic disease. WGCNA id...
ORGANISM(S): Mus musculus 
2009-09-10 | E-GEOD-12748 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type vs glycerol kinase knockout mice to understand the molecular pathogenesis of GKD
Glycerol kinase deficiency (GKD) is an X-linked inborn error of metabolism with metabolic and neurologic crises. Liver shows the highest level of glycerol kinase (GK) activity in humans and mice. Absence of genotype-phenotype correlations in patients with GKD indicate the involvement of modifier gen...
ORGANISM(S): Mus musculus 
2007-12-12 | E-GEOD-3843 | biostudies-arrayexpress
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