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TranscriptomicsExpression profile of MCF7, CCD18 and Ramos human cell lines
To uncover the chromosome 16 associated proteome and to take advantage of the generated knowledge to make progress in human biology in health and disease, a consortium of 15 groups was organized in four working groups: SRM and protein sequencing, antibody and peptide standard, clinical healthcare an...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-40168 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Ramos germinal center B cells
Transcriptional profiling of Ramos germinal center B cells, comparing untreated cells to cells treated with etoposide, and untreated cells to cells treated with anti-IgM. Both treatments, engagement of the B-cell receptor with anti-IgM and induction of DNA double-strand breaks with etoposide, resul...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-23169 | biostudies-arrayexpress
TranscriptomicsChIP-on-chip experiment from Ramos cells to analyze genome-wide CRTC2 binding sites in germinal center B cells
ChIP-on-chip experiment from Ramos cells to analyze genome-wide CRTC2 binding sites in germinal center B cells. The goal was to combine information from our ChIP-on-chip and expression array analyses to compile a list of CRTC2 target genes. CRTC2 was immunoprecipitated from sheared chromatin isolat...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-23170 | biostudies-arrayexpress
ProteomicsThe value of subcellular fractionation for protein identification in a B-cell line (Ramos)
Integrated in the Chromosomic-centric Human Proteome Project (C-HPP), a lymphocytic B-cell line (Ramos) was selected as a model of B-cells. We performed a subfractionation strategy (in triplicate) for the extraction of proteins from 4 different fractions (cytoplasm, CYT; organella, ORG; membrane, MB...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079936 | MassIVE
TranscriptomicsCRTC2 couples genotoxic stress and plasma cell differentiation in the germinal center
This SuperSeries is composed of the following subset Series: GSE23169: Transcriptional profiling of Ramos germinal center B cells GSE23170: ChIP-on-chip experiment from Ramos cells to analyze genome-wide CRTC2 binding sites in germinal center B cells Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-23171 | biostudies-arrayexpress
TranscriptomicsDelta4-BAFF an new transcription factor
The purpose of the study was to identify downstream gene targets regulated by a new alternative splice of BAFF (B-Cell Activating factor belonging to the TNF Family) that we called Delta4-BAFF (because it characterized by an alternative splice of exon 4). To do this we used human burkitt's lymphoma ...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-MEXP-3595 | biostudies-arrayexpress
TranscriptomicsB cell super-enhancers and regulatory clusters recruit AID tumorigenic activity
The antibody gene mutator AID promiscuously damages oncogenes and B cell identity genes leading to chromosomal translocations and tumorigenesis. Why non-immunoglobulin loci are susceptible to AID activity is unknown. Here we study AID-mediated lesions in the context of nuclear architecture and the B...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-62063 | biostudies-arrayexpress
TranscriptomicsRecruitment of MYC to target genes in ramos and mutu3 cells
Follicular lymphomas and diffuse large B-cell lymphomas have markedly different biological phenotypes and yet all originate from mature, germinal center B-cells. We hypothesized that alterations in DNA methylation patterning might help explain the clinical heterogeneity of these diseases. We report ...
ORGANISM(S): Homo sapiens 
2012-11-27 | E-GEOD-31110 | biostudies-arrayexpress
ProteomicsHuman immune cell proteomic library
Comprehensive human immune cell proteomic spectral library which contain CD4+T cell, CD8+ T cell, NK cell, B cell, PBMC, Daudi, Jurkat, stimulated Jurkat, Molt-4, Ramos, and THP-1 were generated. This library includes 10,544 proteins groups, and 127,106 peptides.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-12 | MSV000093644 | MassIVE
TranscriptomicsTranscription profiling of human B-cell lymphoma cell lines treated with motexafin gadolinium and zinc reveals induced oxidative stress responses and apoptosis
There is an emerging appreciation of the importance of zinc in regulating cancer cell growth and proliferation. Recently, we showed that the anticancer agent motexafin gadolinium (MGd) disrupted zinc metabolism in A549 lung cancer cells, leading, in the presence of exogenous zinc, to cell death. Her...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2964 | biostudies-arrayexpress
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