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ProteomicsDifferential kinobeads selectivity profiling
The goal of this project was to use differential kinobeads profiling for the discrimination of reversible and irreversible kinase targets of different covalent kinase inhibitors. For this, differences in target engagement measured in a lysate- and a cell-based kinobeads assay were compared in a kino...
ORGANISM(S): Homo sapiens (Human) 
2017-10-13 | PXD007920 | Pride
Ibrutinib Kinobeads Ramos b-lymphocyte Cell-based assay 5z-7-oxozeaenol Saturated ibrutinib A549 lung epithelia cell line Lysate-based assay Acalabrutinib Cc-292 Lc-ms/ms 
ProteomicsConfirmation of ZAK as covalent target of Ibrutinib
The goal of this experiment was the confirmation of ZAK as a covalent target of Ibrutinib by an affinity enrichment experiment with a linkable analogue of Ibrutinib.
ORGANISM(S): Homo sapiens (Human) 
2017-10-13 | PXD007638 | Pride
Lysate-based assay Linkable ibrutinib affinity enrichment Sds elution vs bead trypsinationlc-ms/ms Ibrutinib Ramos b-lymphocyte lysate 
ProteomicsMicrotubule anchoring and coupling of CD20 to the RhoA/Rock1 pathway (PKCdelta KO SILAC phosphoproteomics)
CD20 is a B cell-specific four-helix transmembrane protein and a prominent target of successful therapeutic anti-CD20 antibodies such as rituximab (RTX) and GA101. We have recently described that CD20 is localized within a membrane nanocluster harboring the IgD class B cell antigen receptor (IgD-BCR...
ORGANISM(S): Homo sapiens (Human) 
2026-04-17 | PXD063667 | Pride
Microtubule network Pkcδ Rhoa/rock1 pathway Mass spectrometry Silac B lymphocyte  cd20 Phosphoproteomics Microtubule-to-actin switch 
TranscriptomicsMapping the inter- and intra-chromosomal interactions of specific insulator binding sites with circular chromosome conformation capture (4C) assay (Gondor et al., 2008 Nature Protocol)
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2013-09-15 | E-GEOD-50769 | biostudies-arrayexpress
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