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UnknownFunctional Analysis of an Essential GSP1/Ran Ortholog Gene, CpRan1, from the Chestnut Blight Fungus Cryphonectria parasitica Using a Heterokaryon.
Not available
S-EPMC8146580 | biostudies-literature
TranscriptomicsRNA-seq analysis of LPS-trained bone marrow derived macrophages (BMDMs) reveals altered glutamine and glycolysis metabolic pathways
The aim of this study is to evaluate data by comparing transcriptome profile (RNA-seq) of BMDMs trained with low-dose LPS and untrained BMDMs. Trained immunity enables innate immune cells to acquire memory-like responses, offering a promising strategy to enhance antitumor immunity. However, the meta...
ORGANISM(S): Mus musculus 
2026-06-24 | E-MTAB-16184 | biostudies-arrayexpress
GenomicsRemodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-dependent transcription factors to bind and function in a cell type-specific manner. Consistent with this model, TLR4 si...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-48759 | biostudies-arrayexpress
GenomicsChIP-seq analysis of LPS trained BMDMs reveals remodeling of Histone 3 Lysine 4 tri-methylation (H3K4me3)
The aim of this study is to profile the distribution of the active histone modification H3K4me3 in BMDMs from WT and SLC1A5_var transgenic mice after low-dose LPS training. We compared the data of ChIP-seq performed on fragmented chromatin immunoprecipitated with anti-H3K4me3 antibody in naive and t...
ORGANISM(S): Mus musculus 
2026-06-24 | E-MTAB-16196 | biostudies-arrayexpress
TranscriptomicsATAC-seq analysis of LPS-trained bone marrow derived macrophages (BMDMs) from WT and SLC1A5_var transgenic mice.
The aim of this study is to evaluate the changes in the chromatin accessibility landscape of BMDMs from WT and SLC1A5_var transgenic mice after low-dose LPS training. We compared the data of ATAC-seq performed on nuclei extracted from naive and trained BMDM from both genotypes. Inter-group compariso...
ORGANISM(S): Mus musculus 
2026-06-24 | E-MTAB-16191 | biostudies-arrayexpress
MetabolomicsJiayi Huatu Decoction mitigates intestinal fibrosis via a gut microbiota–metabolite axis

Ulcerative colitis (UC)-associated intestinal fibrosis represents a serious and currently untreatable complication, highlighting an urgent need for novel therapeutic strategies. This study investigates the therapeutic potential of Jiayi Huatu Decoction (JHD), a traditional Chinese herbal formula ...

2026-02-09 | MTBLS13875 | MetaboLights
TranscriptomicsTLR4/NF-κB-responsive microRNAs in a mouse model of skeletal muscle ischemia-reperfusion injury
TLR4/NF-κB signaling plays a central mediator in response to danger signals released in the muscle ischemia-reperfusion injury (IRI). This study was designed to profile TLR4/NF-κB-responsive microRNAs (miRNAs) in the skeletal muscles following IRI. Following 2 h of ischemia and subsequent reperfus...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-47730 | biostudies-arrayexpress
UnknownGRPR-induced FAM135A expression promote perineural invasion in prostate cancer.
Not available
S-EPMC12625755 | biostudies-literature
TranscriptomicsDigital gene expression analysis reveals genes associated with hexythiazox resistance in citrus red mite, Panonychus citri
We compared a miticides resistant strain and a susceptible strain's gene expression profile to reveal genes associated with miticide resistance in Panonychus citri.
ORGANISM(S): Panonychus citri 
2013-06-11 | E-MTAB-1193 | biostudies-arrayexpress
GenomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (MeDIP-Seq)
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we used the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modif...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-33129 | biostudies-arrayexpress
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