Sort   by:  
 Page size 
ProteomicsCGG repeat RNA binding protein capture identifies SRSF protein kinase 1 as a modulator of RAN translation and suppressor of repeat toxicity
Transcribed CGG repeat expansions cause the neurodegenerative disorder Fragile X-associated tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA-binding proteins (RBPs) into nuclear foci and undergo repeat-associated non-AUG (RAN) translation into toxic peptides in the cytoplasm. To identif...
ORGANISM(S): Homo sapiens (Human) 
2021-09-28 | PXD027000 | Pride
Ran translation Repeat rna 
UnknownA survivin-ran complex regulates spindle formation in tumor cells.
Not available
S-EPMC2519733 | biostudies-literature
MetabolomicsLongitudinal metabolomics and lipidomics analyses reveal markers of envenoming by Bothrops asper and Daboia russelii in an experimental murine model

Longitudinal metabolomics and lipidomics analysis was carried out in the blood plasma of mice injected intramuscularly with venoms of the viperid species Bothrops asper and Daboia russelii. Blood samples were collected 1, 3, 6 and 24 h after venom injection, and a control group ...

2022-09-21 | MTBLS5430 | MetaboLights
TranscriptomicsMaternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response.
Maternal immune activation is a risk factor for the development of schizophrenia and autism. Infections during pregnancy activate the mother's immune system and alter the fetal environment with sub-sequence effects of CNS function and behavior in the offspring, but the cellular and molecular links b...
ORGANISM(S): Rattus norvegicus 
2012-07-25 | E-GEOD-34058 | biostudies-arrayexpress
ModelsSmithAE2002_RanTransport
The model reproduces the compartmental model for Ran transport as depicted in Fig 3 of the paper. Model reproduced using MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldw...
2024-09-02 | BIOMD0000000164 | BioModels
UnknownMerging Directed C-H Activations with High-Throughput Experimentation: Development of Iridium-Catalyzed C-H Aminations Applicable to Late-Stage Functionalization.
Not available
S-EPMC9088304 | biostudies-literature
TranscriptomicsExpression data of mouse preoptic region 5 h after LPS-administration comparing wt and mPGES-1 KO mice.
WT mice and mPGES-1 KO mice were treated with 120 mikrogram/kg LPS and sacrificed 5 h later. The preoptic region was dissected by LCM and analyzed using GeneChip Mouse Genome 430 2.0 arrays (Affymetrix). Groups: WT LPS-treated versus mPGES-1 KO LPS-treated mice.
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43181 | biostudies-arrayexpress
ProteomicsThe nucleoporin Nup50 activates the Ran guanyl-nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis
During mitotic exit, thousands of nuclear pore complexes (NPCs) assemble concomitant with the nuclear envelope to build a transport-competent nucleus. Here, we show that Nup50 plays a crucial role in NPC assembly independent of its well-established function in nuclear transport. RNAi-mediated downre...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028701 | Pride
Ap-ms Nuclear pore complex Xenopus 
TranscriptomicsH. pylori infection blocks DNA damage induced apoptosis by T4SS-dependent upregulation of miR-155
The innate immune response against Helicobacter pylori is mainly controlled by pattern recognition receptors that lead to the up-regulation of pro-inflammatory cytokines. A new player in this field is the miR-155 being regulated by TLR ligands in monocytic derived cells influencing certain intracell...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-29388 | biostudies-arrayexpress
UnknownMapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis.
Not available
S-EPMC11019168 | biostudies-literature
Sort   by:  
 Page size