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UnknownReduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology.
Not available
S-EPMC3540085 | biostudies-literature
UnknownRegulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.
Not available
S-EPMC7250854 | biostudies-literature
Transcriptomics17b-Trenbolone study
We investigated the genomic transcriptional response of female fathead minnows (Pimephales promelas) to an acute (4 day) exposure to 0.1 or 1.0 µg/L of, 17β-trenbolone (TB), the active metabolite of an anabolic androgenic steroid used as a growth promoter in cattle and a contaminant of concern in ...
ORGANISM(S): Pimephales promelas 
2010-05-14 | E-GEOD-12904 | biostudies-arrayexpress
TranscriptomicsMolecular Characterization of In Vivo Adjuvant Activity in Ferrets Vaccinated against Influenza Virus
The 2009 H1N1 influenza pandemic has prompted a significant need for the development of efficient, single-dose, adjuvanted vaccines. Here we investigated the adjuvant potential of CpG oligodeoxynucleotide (ODN) when used with a human seasonal influenza virus vaccine in ferrets. We found that the CpG...
ORGANISM(S): Mustela putorius furo 
2011-02-11 | E-GEOD-27248 | biostudies-arrayexpress
TranscriptomicsThe evolution of spinable cotton fiber entailed prolonged development and a novel metabolism
exceptional example of evolutionary innovation is the single-celled seed trichome in Gossypium ("cotton fiber"). We have used fiber development in Gossypium as a system to understand how morphology can rapidly evolve. Fiber has undergone considerable morphological changes between the short, tightly...
ORGANISM(S): Gossypium herbaceum 
2010-06-25 | E-GEOD-10228 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of ATM, p53 Rel_A subunit of NFkB or LacZ in human HEK293 cells treated with the radiomimetic drug NCS
Response to treatment with the radiomimetic drug NCS in cells knocked-down for ATM, p53, and the Rel_A subunit of NFkB; and in control un-infected cells and cells infected with siRNA against LacZ
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-1676 | biostudies-arrayexpress
UnknownEffects of salt stress on the photosynthetic physiology and mineral ion absorption and distribution in white willow (Salix alba L.).
Not available
S-EPMC8601552 | biostudies-literature
TranscriptomicsMicroarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells
Cannabinoids are known to exert immunosuppressive activities. However, the mechanisms which contribute to these effects are unknown. Using lipopolysaccharide (LPS) to activate BV-2 microglial cells, we examined how Δ9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, and can...
ORGANISM(S): Mus musculus 
2015-07-09 | E-GEOD-70689 | biostudies-arrayexpress
TranscriptomicsEarly CCL2 and CXCL10 chemokine expression correlates with lung pathology in Pandemic H1N1 Influenza A infection
Background: Pandemic H1N1 influenza A is a newly emerging strain of human influenza that is easily transmitted between people and has spread globally to over 116 countries. Human infection leads to symptoms ranging from mild to severe with lower respiratory complications observed in a small but sign...
ORGANISM(S): Mustela putorius furo 
2010-04-12 | E-GEOD-17079 | biostudies-arrayexpress
GenomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [ChIP-seq]
Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardi...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47082 | biostudies-arrayexpress
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