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TranscriptomicsRNA-seq analysis of MG1655 Escherichia coli (Wild-type, and mutants lacking the glucose metabolism regulator TmaR) experiencing short- & long-term N starvation and following treatment with rifampicin during long-term N starvation in Gutnick minimal media
RNA-seq was carried out to compare the transcriptomes of wild-type MG1655 E coli with mutants lacking the glucose metabolism regulator TmaR , in bacteria that had been exposed to short-term (3hr) and long-term (24hr) nitrogen starvation in Gutnick minimal media. A rifampicin-chase experiment was per...
ORGANISM(S): Escherichia coli K-12 
2025-09-23 | E-MTAB-15469 | biostudies-arrayexpress
TranscriptomicsC9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD
Noncoding expansions of a hexanucleotide repeat (GGGGCC) in the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. Here we report transgenic mice carrying a bacterial artificial chromosome (BAC) containing the full human C9orf72 gene with ei...
ORGANISM(S): Mus musculus 
2016-02-10 | E-GEOD-77720 | biostudies-arrayexpress
UnknownThe methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.
Not available
S-EPMC2898669 | biostudies-literature
ProteomicsN-glycoproteomics and SESTAR++ analysis based on SeMOE
The isotopic envelope pattern of selenium is guaranteed by its six stable isotopes with distinctive distribution (74Se, 0.89%; 76Se, 9.37%; 77Se, 7.63%; 78Se, 23.77%; 80Se, 49.61%; 82Se, 8.73%). We postulated that the effective incorporation of selenosugar in glycoproteins would achieve direct isoto...
ORGANISM(S): Homo sapiens (Human) 
2023-11-20 | PXD042137 | Pride
Human N-glycoproteomics Hela cell Sestar Semoe 
ProteomicsThe nucleoporin Nup50 activates the Ran guanyl-nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis
During mitotic exit, thousands of nuclear pore complexes (NPCs) assemble concomitant with the nuclear envelope to build a transport-competent nucleus. Here, we show that Nup50 plays a crucial role in NPC assembly independent of its well-established function in nuclear transport. RNAi-mediated downre...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028701 | Pride
Ap-ms Nuclear pore complex Xenopus 
ProteomicsIntegrative Proteomics and N-Glycoproteomics Reveals the Synergistic Anti-tumor Effects of Aspirin and Gemcitabine-based Chemotherapy on Pancreatic Cancer Cells
Based on an integrated multi-omics based on quantitative N-glycoproteomes analysis strategy, we investigated their synergistic anti-tumor effects and explored the potential molecular mechanisms and biological functions underlying their inhibitory effects on the development of pancreatic cancer.
ORGANISM(S): Homo Sapiens 
2023-04-10 | PXD041445 |
ModelsSmithAE2002_RanTransport
The model reproduces the compartmental model for Ran transport as depicted in Fig 3 of the paper. Model reproduced using MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldw...
2024-09-02 | BIOMD0000000164 | BioModels
TranscriptomicsUNG shapes the specifity of AID-induced somatic hypermutation in B cells
Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes. The resulting U:G mis...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39114 | biostudies-arrayexpress
TranscriptomicsColistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids and poly-beta-1,6-N-acetylglucosamine
We recently demonstrated that colistin resistance in Acinetobacter baumannii can result from mutational inactivation of genes essential for lipid A biosynthesis. Consequently, strains harboring these mutations are unable to produce the major Gram negative bacterial surface component, lipopolysacchar...
ORGANISM(S): Acinetobacter baumannii 
2011-08-11 | E-GEOD-31206 | biostudies-arrayexpress
TranscriptomicsRNA-seq of non-LPS treated (N), non-tolerized (NT), and tolerized (T) IFNg-primed macrophages pretreated with or without HDAC3i
In this experiment we investigated the effect of HDAC3 inhibition on the transcriptome of IFNg-primed macrophages under different tolerization conditions. Peripheral blood mononuclear cells (PBMCs) were isolated from 3 healthy donors. PBMCs were isolated from whole blood of healthy donors using Fico...
ORGANISM(S): Homo sapiens 
2020-02-12 | E-MTAB-8784 | biostudies-arrayexpress
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