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CTCF sites are abundant in the genomes of diverse species but their function is enigmatic. We used chromosome conformation capture to determine long-range interactions among CTCF/cohesin sites over 2 Mb on human chromosome 11 encompassing the β-globin locus and flanking olfactory receptor genes. Alt...
ORGANISM(S): Homo sapiens 
TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate TDP-43 in neurons are not well understood. We generated a Halo-TDP-43 knock-in iPSC line and performed a genome-wide CRISPR interference FACS-based screen to identify modifiers of...
ORGANISM(S): Homo sapiens (Human) 
2025-08-01 | PXD063206 | Pride
This project uses untargeted proteomics to investigate how cellular metabolic state and metabolite adjuvants regulate extracellular vesicle (EV) uptake in neuroblastoma cells. Proteomic profiling was performed on cells cultured in in vivo–like medium (HPLM) or standard medium, as well as on HPLM-con...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD072838 | Pride
This dataset contains untargeted proteomic measurements from H441 epithelial cells cultured under physiologic metabolic conditions. Cells were conditioned in human plasma–like medium (HPLM) and treated with or without an amino acid supplement. Proteomic profiling was performed to quantify global pr...
ORGANISM(S): Homo sapiens (Human) 
2026-03-11 | PXD072867 | Pride
We investigated the association between subgingival bacterial profiles and gene expression patterns in gingival tissues of patients with periodontitis. A total of 120 patients undergoing periodontal surgery contributed with a minimum of two interproximal gingival papillae (range 2-4) from a maxillar...
ORGANISM(S): Homo sapiens 
Molecular prognostic assays, such as Oncotype DX, are increasingly incorporated into the management of patients with invasive breast carcinoma. BreastPRS is a new molecular assay developed and validated from a meta-analysis of publically available genomic datasets. We applied the assay to matched fr...
ORGANISM(S): Homo sapiens 
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