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MGMT promoter methylation status is currently the only established molecular prognosticator in IDH wild-type glioblastoma multiforme (GBM). Therefore, we aimed to discover novel therapy-associated epigenetic biomarkers. After enrichment for hypermethylated fractions using methyl-CpG-immunoprecipitat...
ORGANISM(S): Homo sapiens 
Aging impacts on the plasticity and biochemistry of skeletal muscle. For a deeper understanding of skeletal muscle function in aging and sarcopenia, defined as age related muscle decline, the identification of molecular signatures regulating muscle function under physiological conditions is importan...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049424 | Pride
Mutations in KDM5C, (previously named SMCX or JARID1C) a gene that encodes a transcriptional regulator with histone-demethylase activity specific for di- and tri-methylated H3K4, are a comparatively frequent cause of non-syndromic X-linked mental retardation (NS-XLMR). Specific transcriptional targe...
ORGANISM(S): Homo sapiens 
Cysteinyl leukotrienes (cysLT), i.e. LTC4, LTD4, and LTE4, are lipid mediators derived from the 5-lipoxygenase pathway. The cysLT receptors cysLT1-R and cysLT2-R are expressed on different target cells and mediate inflammatory reactions in tissue- and LT-R-specific ways. Though endothelial cells (EC...
ORGANISM(S): Homo sapiens 
Miniaturization of sample preparation including omissible manual sample handling steps is key for reproducible nanoproteomics as material is often restricted to only hundreds of cells or single model organisms. Here, we demonstrate a highly sensitive digital microfluidics (DMF)-based sample preparat...
ORGANISM(S): Caenorhabditis elegans 
2022-08-12 | PXD033143 | Pride
Application of a novel TiO2-based phosphopeptide enrichment protocol to study the role of protein arginine phosphorylation in B.subtilis. 1 iTRAQ Quantification of pArg peptides in B.subtilis upon heat shock and oxidative stress in comparison to unstressed control 2 Studying pArg upon deletion of M...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2013-11-21 | PXD000273 | Pride
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