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MetabolomicsUntargeted LC-MS metabolomics of RANKL-differentiated Bone Marrow–Derived Macrophages ± Bacillus Calmette–Guérin (BCG) exposure

To investigate the metabolites and pathways modulated by BCG in RANKL-differentiated macrophages, thereby elucidating the metabolic mechanisms underlying BCG-induced macrophage activation, BMMs were stimulated with 50 ng/mL RANKL for 5 days to generate osteoclast-like cells. Subsequently, one gro...

2026-03-31 | MTBLS12992 | MetaboLights
TranscriptomicsGene expression analysis of transcriptome changes regulated by RANKL-RANK signaling in macrophage cell line RAW 264.7
Bone remodeling relies on the precise developmental control of osteoclasts that resorb bone and osteoblasts that lay down fresh bone matrix. The hematopoietically derived osteoclast follow a tigthly controlled genetic program where specific genes are up-regulated to aid bone resorption.Some of them ...
ORGANISM(S): Mus musculus 
2010-08-24 | E-GEOD-21639 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bone marrow derived cells from mice stimulated with RANKL to generate osteoclasts in a time series
Bone marrow derived cells stimulated with RANKL (receptor activator of nuclear factor kappa B ligand, also known as Tumor necrosis factor ligand superfamily member 11) to generate osteoclasts.
ORGANISM(S): Mus musculus 
2007-06-06 | E-TABM-212 | biostudies-arrayexpress
TranscriptomicsMicroarray studies on genes stimulated by RANKL in bone marrow macrophages in a cyclooxygenase-2-dependent manner
Overall goal was to look for the differentially expressed genes between receptor activator of nuclear factor kappa-B ligand (RANKL)-stimulated wild type (WT) bone marrow macrophages (BMMs) and the BMMs in which the expression or the enzyme activity of cyclooxygenase-2 (Cox2), the major enzyme for pr...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-72047 | biostudies-arrayexpress
TranscriptomicsEffect of GDF11 on RANKL-induced osteoclastogenesis
GDF11 treatment leads to bone loss in mice and strongly stimulates RANKL-induced osteoclastogenesis of bone marrow-“derived macrophages (BMMs) in vitro. We used microarrays to identified distinct classes of up-regulated genes in BMMs after GDF11 treatment. Mouse BMMs were treated with or without GD...
ORGANISM(S): Mus musculus 
2016-07-21 | E-GEOD-84609 | biostudies-arrayexpress
TranscriptomicsGene expression profile of murine intestinal epithelial cells after RANKL treatment
RANKL (receptor acrivator of NFkB ligand) is a member of TNF superfamily cytokines. In the gastrointestinal tract, RANKL is expressed in the stromal cells of Peyer's patches, and involved in the development of the specialized intestinal epithelial cells, called M cells. To identify the genes involve...
ORGANISM(S): Mus musculus 
2012-06-16 | E-GEOD-37861 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling in bone marrow-derived macrophage (BMM) cells upon RANKL treatment
To screen for altered gene expression during osteoclastogenesis, RANKL-treated BMM cells were subjected to gene expression profiling. BMM cells were treated with M-CSF and RANKL for 0, 1, 2 and 3 days. Total RNA was isolated and analyzed by gene expression microarray using the MouseRef-8 v2.0 Expres...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-57468 | biostudies-arrayexpress
TranscriptomicsRAW264.7 cells: RANKL vs Bone Metastasis Tumor Cell Condidtioned Media
Transcriptional profiling of differential miRNA expression in mouse RAW264.7 preosteoclast cells comparing control untreated cells with RAW264.7 cells treated for 6 days. Treatment conditiones tested included 50ng/mL RANKL or indicated bone metastasis tumor cell conditioned media from 4T1, 4T1.2, TS...
ORGANISM(S): Mus musculus 
2013-10-14 | E-GEOD-44936 | biostudies-arrayexpress
TranscriptomicsMurine Bone Marrow Macrophages: Control vs. RANKL Stimulated
To identify the microRNAs that are involved in osteoclastogenesis, microRNA expression profiles in mouse bone marrow macrophages (BMMs) stimulated with RANKL (BMOc) were compared with that of control untreated BMMs. These results provide insights into the mechanisms to regulate osteoclastogenesis an...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-48629 | biostudies-arrayexpress
TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
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