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MetabolomicsMetabolomics Study of Serum and Urine Samples Reveals Metabolic Pathways and Biomarkers Associated with Pelvic Organ Prolapse
Pelvic organ prolapse (POP) is a common medical condition among women and involves complicated diagnostics and controversial surgical management. The exact molecular mechanism underlying POP is poorly understood, especially at the metabolism level. To explore the metabolic mechanism underlying POP a...
2019-08-14 | MTBLS1033 | MetaboLights
UnknownNFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.
Not available
S-EPMC22056 | biostudies-literature
MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
TranscriptomicsATF3 is a positive regulator of human IFN gene expression
The aim of this study was to identify genes regulated by IL-12, IL-18 and IFN-alpha during early differentiation of human Th1 cells Human cord blood CD4+ T cells were activated via TCR and cultured in the presence of IL-12, IFN-alpha or IL-12+IL-18. Cytokine induced gene expression was compared to a...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-20198 | biostudies-arrayexpress
ProteomicsDIA-PRM Proteomic Study of Tissue Samples Reveals Modulated Pathways and Biomarkers Related to Pelvic Organ Prolapse
To discover potential biomarker(s) for POP diagnosis and explore the molecular mechanism underlying the disease, we here applied an untargeted data-independent acquisition (DIA)-based proteomics approach on vaginal wall tissue samples from patients with POP (n = 19) and controls (n = 8).
ORGANISM(S): Homo Sapiens 
2023-05-25 | PXD042491 |
ProteomicsIdentification of key elements and pathways regulated by Yiqi Sanjie formula against colorectal cancer based on integrative analyses
The Yiqi Sanjie (YQSJ) formula has been proved to be clinically useful for stage III colorectal cancer (CRC) patients. However, the exact anti-tumor mechanisms of YQSJ and its main active component peiminine remain incompletely understood. This study aimed to comprehensively explore the characteriza...
ORGANISM(S): Homo Sapiens 
PXD037110 |
ProteomicsIntegrated tissue proteome and metabolome reveal key elements and regulatory pathways in cutaneous squamous cell carcinoma
we took advantage of nanoscale liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (nanoLC/Q-TOF-MS/MS) and ultraperformance LC/Q-TOF-MS/MS techniques on cancer and the corresponding paracancerous tissues from 20 CSCC patients for integrated proteomic and metabolomic analyse...
ORGANISM(S): Homo Sapiens 
2021-01-20 | PXD023716 |
UnknownGut microbiota components are associated with fixed airway obstruction in asthmatic patients living in the tropics.
Not available
S-EPMC6018556 | biostudies-literature
UnknownOrigin of biological homochirality by crystallization of an RNA precursor on a magnetic surface
Not available
S-EPMC10246896 | biostudies-literature
UnknownPrediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids.
Not available
S-EPMC2995806 | biostudies-literature
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