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TranscriptomicsArabidopsis transcription factor ANAC017 is a necessary and central control point for normal transcriptome changes in response to reactive oxygen signals, such as H2O2, and specific mitochondrial retrograde stress signals
Stresses that target mitochondrial function lead to altered transcriptional responses for 100-1000s of genes genome wide, and are signalled via retrograde communication pathways within the cell. rao2 mutants contain a mutation in the NAC family transcription factor ANAC017 and cannot induce stress r...
ORGANISM(S): Arabidopsis thaliana 
2013-01-30 | E-GEOD-41136 | biostudies-arrayexpress
UnknownRNF213 c.14429G > A (p.Arg4810Lys) is associated with non-arteritic retinal artery occlusion.
Not available
S-EPMC12514059 | biostudies-literature
ProteomicsCo-Immunoprecipitation of TMEM65
Mitochondrial Ca2+ transport is a critical process in cellular physiology. One pathway for export occurs via Na+/Ca2+exchange (mito-NCX) machinery. TMEM65 has recently been shown to be crucial for mito-NCX activity, but its precise mechanistic role remains unknown. To evaluate whether TMEM65 forms a...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD064897 | Pride
Co-ip Lc-ms/ms 
TranscriptomicsSix in situ Hi-C libraries of control and mESC auxin-inducible degrons for Scc1 and Ring1b.
In this experiment, we've examined chromatin conformation differences of E14 mESC against cohesin and Ring1b degrons. We performed a modified in situ Hi-C protocol from (Rao et al., 2014) that can be found in detail at (Díaz et al., 2018). Samples were digested with MboI restriction enzyme. The aim ...
ORGANISM(S): Mus musculus 
2020-01-23 | E-MTAB-7816 | biostudies-arrayexpress
TranscriptomicsFour Hi-C datasets from mESCs and 2C-like cells generated by knocking down the histone chaperone CAF-1 in mESCs
In this experiment, we've examined chromatin conformation of mESCs and 2C-like cells generated from a CAF-1 knockdown. The method to generate the knockdown was described in (). We performed a modified in situ Hi-C protocol from (Rao et al., 2014) and that can be found in detail at (Díaz et al., 2017...
ORGANISM(S): Mus musculus 
2023-11-16 | E-MTAB-6330 | biostudies-arrayexpress
TranscriptomicsGenome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
5hmC and TET proteins have been implicated in stem cell biology and cancer, but information on the genome-wide distribution of 5hmC is limited. Here we describe two novel and specific approaches to profile the genomic localisation of 5hmC. The first approach, termed GLIB (GLucosylation, perIodate o...
ORGANISM(S): Mus musculus 
2011-04-21 | E-GEOD-28682 | biostudies-arrayexpress
TranscriptomicscDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype
Mammary cancer is the most common type of cancer in female dogs with a lifetime risk of over 24% when dogs are not spayed. The elucidation of the complete canine genome opens new areas for development of cancer therapies. These should be tested first by in vitro models such as cell lines. However, t...
ORGANISM(S): Canis lupus familiaris 
2007-09-01 | E-GEOD-7659 | biostudies-arrayexpress
UnknownVascular biomarkers and digital ulcerations in systemic sclerosis: results from a randomized controlled trial of oral treprostinil (DISTOL-1).
Not available
S-EPMC8211019 | biostudies-literature
UnknownNear-vision impairment and effective near-vision spectacle coverage in two districts in Telangana, India: a population-based cross-sectional study.
Not available
S-EPMC8030469 | biostudies-literature
GenomicsCo-activation of GR and NF-kB leads to extensive rearrangemnet of their binding sites and target genes
Global identification of activated GR and p65 binding sites and target genes using ChIP-seq in HeLa B2 cells. generation genome-wide chromatin state-maps of GR, p65 and RNAPII in HeLa B2 cells under conditions 1) DMSO (control); 2) TA 1M-BM-5M 4hr; 3) TNFM-NM-1 10ng/ml ; 4) TA 1M-BM-5M 4hr at at th...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-24518 | biostudies-arrayexpress
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