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ProteomicsChromosome end protection by RAP1-mediated inhibition of DNA-PK
During classical non-homologous end joining (cNHEJ), DNA-dependent protein kinase (DNA-PK) encapsulates free DNA ends, forming a recruitment platform for downstream end-joining factors including Ligase 4 (LIG4). DNA-PK can also bind telomeres, but does not initiate cNHEJ at this position. How the en...
ORGANISM(S): Homo sapiens (Human) 
2025-02-25 | PXD047643 | Pride
Rap1 Dna-pk Rap1-mediated inhibition Crosslinking 
UnknownMultiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions.
Not available
S-EPMC7549671 | biostudies-literature
UnknownActive Rap1-mediated inhibition of choroidal neovascularization requires interactions with IQGAP1 in choroidal endothelial cells.
Not available
S-EPMC8238370 | biostudies-literature
UnknownEPAC-RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP.
Not available
S-EPMC6309370 | biostudies-literature
UnknownChromosome end protection by RAP1-mediated inhibition of DNA-PK.
Not available
S-EPMC12221994 | biostudies-literature
GenomicsGenome-wide analysis reveals that budding yeast Rif1 binds to replication origins and at blocked replication forks to protect nascent DNA
This experiment details ChIP sequencing to decipher the binding sites of the Rif1 protein in budding yeast. Rif1 binds most strongly to telomeres where its binding is mediated by Rap1. To reduce telomere binding and help reveal Rap1-independent binding sites, a truncation mutant of Rif1 lacking the ...
ORGANISM(S): Saccharomyces cerevisiae 
2018-12-31 | E-MTAB-6736 | biostudies-arrayexpress
UnknownARAP1 fine-tunes F-actin polymerization level in lymphocytes through RhoA inhibition.
Not available
S-EPMC12756398 | biostudies-literature
TranscriptomicsRoles of mammalian Rap1 in TERT recruitment to chromatin, subtelomeric gene silencing and transcriptional regulation
Repressor-activator protein 1 (scRap1) is the major binding activity at Saccharomyces cerevisiae telomeres, with roles in telomere length regulation and establishment of subtelomeric silencing by recruiting the Sir proteins. scRap1 also acts as a transcription factor controlling the expression of ri...
ORGANISM(S): Mus musculus 
2010-07-10 | E-GEOD-19011 | biostudies-arrayexpress
UnknownCell cycle-dependent inhibition of 53BP1 signaling by BRCA1.
Not available
S-EPMC4860855 | biostudies-literature
UnknownHost cell cAMP-Epac-Rap1b pathway inhibition by hawthorn extract as a potential target against Trypanosoma cruzi infection.
Not available
S-EPMC10754523 | biostudies-literature
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