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ProteomicsQuantitative phosphoproteomic analysis of DNA-PK substrates
We conducted a TMT based phosphoproteomic analysis to identify DNA-PK substrates.
ORGANISM(S): Homo Sapiens 
2023-01-15 | PXD039454 |
ProteomicsIntegrative Structural Model of DNA-PK Synapsis
In non-homologous end joining repair of DNA double strand breaks, DNA dependent protein kinase catalytic subunit (DNA-PKcs) and Ku70/80 binds the free DNA ends forming the holoenzyme DNA-PK. DNA-PK synapses across the break to tether the broken ends in the initial long range synaptic complex. We gen...
ORGANISM(S): Homo sapiens (Human) 
2021-01-20 | PXD017931 | Pride
Dna-pk Hydrogen deuterium exchange Crosslinking 
ProteomicsSynergistic targeting of DNA-PK and KIT signaling pathways in KIT mutant acute myeloid leukemia
Acute Myeloid Leukemia (AML) is the most common and aggressive form of acute leukemia, with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating mutations in kinases, such as the receptor tyrosine kinases FLT3 and KIT. FLT3 and KIT mutations are associated with poor...
ORGANISM(S): Mus Musculus 
2023-01-26 | PXD030214 | panorama
ProteomicsChromosome end protection by RAP1-mediated inhibition of DNA-PK
During classical non-homologous end joining (cNHEJ), DNA-dependent protein kinase (DNA-PK) encapsulates free DNA ends, forming a recruitment platform for downstream end-joining factors including Ligase 4 (LIG4). DNA-PK can also bind telomeres, but does not initiate cNHEJ at this position. How the en...
ORGANISM(S): Homo sapiens (Human) 
2025-02-25 | PXD047643 | Pride
Rap1 Dna-pk Rap1-mediated inhibition Crosslinking 
ProteomicshSSB1 DNA-binding is modulated by dynamic DNA-PK-mediated phosphorylation
The maintenance of genomic stability is essential for cellular viability and the prevention of diseases such as cancer. Human single-stranded DNA binding protein 1 (hSSB1) is a protein with roles in the stabilisation and restart of stalled DNA replication forks, as well as in the repair of oxidative...
ORGANISM(S): Homo sapiens (Human) 
2018-02-07 | PXD003964 | Pride
Human / hssb1 / dna-pk / ppp family phosphatase / replication stress / hydroxyurea / sciex 5600 
ProteomicsSystematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity
Rapid and dynamically shifting protein-protein interactions (PPIs) underlie the capacity of cells to recognize viral infections and ignite the downstream cascades that constitute the innate-immune response. Herpesviruses share an ancient history of coevolution with their hosts and have developed rec...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2021-05-11 | PXD023167 | Pride
Thermal proteome profiling  herpes simplex virus 1  protein complexes  protein interactions  ifi16  dna sensing  dna-pk  dna damage response  innate immunity 
ProteomicsDNA-PK Phosphoproteomic Profiling during HSV-1 and DNA
HFF cells were infected with ICP0 RF HSV-1 (MOI 5), treated with bleomycin (10mg/mL), or left untreated as a control. Nu-7441 (DNA-PK inhibitor; 2uM)or DMSO (Control) was applied after 1 hour then samples were harvested after 1 hour for bleomycin treated cells or 6 hours for HSV-1 infected cells.
ORGANISM(S): Homo sapiens (Human) 
2024-10-07 | PXD044489 | Pride
Bleomycin Dna-pk Hsv-1 Human foreskin fibroblasts 
GenomicsPleiotropic impact of DNA-PK in cancer and implications to therapeutic strategies
Pleiotropic impact of DNA-PK in cancer and implications to therapeutic strategies
PRJNA480169 | ENA
ProteomicsUbiquitin ligase WWP2 targets RNA polymerase II in a DNA-PK-dependent transcription shutoff circuitry for DNA repair
DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII)-transcribed genes lead to inhibition of transcription. DNA protein kinase (DNA-PK) complex plays a pivotal role in transcription inhibition at DSBs by stimulating proteasome-dependent eviction of RNAPII at these lesions. How DNA-PK trigge...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD012606 | Pride
Human 
GenomicsDNA-PK Promotes DNA End Resection at DNA Double Strand Breaks in G0 cells [ChIP-Seq]
DNA-PK Promotes DNA End Resection at DNA Double Strand Breaks in G0 cells [ChIP-Seq]
PRJNA772575 | ENA
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