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ProteomicsRecoding multiple rare codons enables the simultaneous incorporation of up to five distinct noncanonical amino acids
Expanding the genetic code has revolutionized our ability to study and manipulate biological systems through site-specific incorporation of noncanonical amino acids (ncAAs). However, current methods are primarily limited to single-type ncAA incorporation in mammalian cells owing to translation ineff...
ORGANISM(S): Homo Sapiens 
2025-11-04 | PXD070277 |
TranscriptomicsThe anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria
Protein synthesis by ribosomes takes place on a linear substrate but at variable speeds. Transient pausing of ribosomes can impact a variety of co-translational processes, including protein targeting and folding. These pauses are influenced by the sequence of the mRNA. Thus redundancy in the genetic...
ORGANISM(S): Escherichia coli 
2012-04-01 | E-GEOD-35641 | biostudies-arrayexpress
ProteomicsA rare-codon-based translational program of cell proliferation
The codon usage of mRNAs controls the speed of translation elongation, which is primarily determined by the abundance of cognate tRNAs. By profiling mRNA expression around the cell cycle we found that mRNAs that are relatively upregulate in the G2/M phase are enriched in rare codons. To understand ...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-21 | PXD016034 | Pride
Cell proliferation Codon usage Translation elongation Rare codons Lfq Trna pools Translation control 
MetabolomicsVirus-induced codon-specific reprogramming to favor viral RNA translation
Recent evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express their genomes at high levels despite an enrichment in rare codons remains a puzzling question. Using ribosome footprinting, here we analysed ...
2025-06-16 | MTBLS2443 | MetaboLights
UnknownAnalysis of the distribution of functionally relevant rare codons.
Not available
S-EPMC2391168 | biostudies-literature
UnknownWidespread position-specific conservation of synonymous rare codons within coding sequences.
Not available
S-EPMC5438181 | biostudies-literature
UnknownExpression of transgenes enriched in rare codons is enhanced by the MAPK pathway.
Not available
S-EPMC7746698 | biostudies-literature
UnknownIn-silico Evaluation of Rare Codons and their Positions in the Structure of ATP8b1 Gene.
Not available
S-EPMC6409373 | biostudies-literature
UnknowneRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons.
Not available
S-EPMC6755126 | biostudies-literature
UnknownConserved regional 3' grouping of rare codons in the coding sequence of ocular prosecretory mitogen lacritin.
Not available
S-EPMC3604909 | biostudies-literature
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