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UnknownRapid protein stability prediction using deep learning representations.
Not available
S-EPMC10266766 | biostudies-literature
ProteomicsElucidating PTEN Conformational Dynamics and Phosphatase Regulation via Integrative Modeling and Mutation Prediction
PTEN (Phosphatase and TENsin homolog deleted on chromosome ten) is a major tumor suppressor gene that is frequently mutated or lost under cancerous conditions. PTEN is a dual-specificity phosphatase that negatively regulates the PI3K/AKT/mTOR signaling pathway at the plasma membrane (PM). Its functi...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD059974 | Pride
Molecular dynamics Molecular modeling Molecular biology Conformational change Rasp stability prediction Crosslinking mass spectrometry (xl-ms) Alphamissense Clinical mutation Integrative structural modeling Phosphatase and tensin homolog (pten) 
ProteomicsElucidating PTEN Conformational Dynamics and Phosphatase Regulation via Integrative Modeling and Mutation Prediction
PTEN-WT and PTEN-4A models generation using Rosetta restrained with XL-MS crosslink distance restraints. Two major conformations of each protein were modeled
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD060469 | Pride
Molecular dynamics Molecular modeling Molecular biology Conformational change Rasp stability prediction Crosslinking mass spectrometry (xl-ms) Alphamissense Clinical mutation Integrative structural modeling Phosphatase and tensin homolog (pten) 
TranscriptomicsPrediction of gene activity based on an integrated multi-omics approach.
An increasingly common method for predicting gene activity is genome-wide chromatin immunoprecipitation of M-bM-^@M-^XactiveM-bM-^@M-^Y chromatin modifications followed by massively parallel sequencing (ChIP-seq). Using a novel ChIP-seq quantification method (cRPKM), we tested the power of such ChIP...
ORGANISM(S): Mus musculus 
2013-11-19 | E-GEOD-52450 | biostudies-arrayexpress
UnknownNeural general circulation models for weather and climate.
Not available
S-EPMC11357988 | biostudies-literature
TranscriptomicsmiR-143-5p suppresses breast cancer progression by targeting the HIF-1α-related GLUT1 pathway
Breast cancer (BC) is a commonly identified life-threatening type of cancer and a major cause of death among women worldwide. Several microRNAs (miRs), including miR-143-5p, have been reported to be vital for regulating hallmarks of cancer; however, the effect of miR-143-5p on BC requires further ex...
ORGANISM(S): Homo sapiens 
2022-02-26 | E-MTAB-11160 | biostudies-arrayexpress
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