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TranscriptomicsGenome-wide quantitative enhancer activity maps identified by STARR-seq
Genomic enhancers are important regulators of gene expression, but their identification is a challenge and methods depend on indirect measures of activity. We developed a method termed STARR-seq to directly and quantitatively assess enhancer activity for millions of candidates from arbitrary sources...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-GEOD-40739 | biostudies-arrayexpress
TranscriptomicsDissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features
Gene expression is determined by genomic elements called enhancers, which contain short motifs bound by different transcription factors (TFs). However, how enhancer sequences and TF motifs relate to enhancer activity is unknown and general sequence requirements for enhancers or comprehensive sets of...
ORGANISM(S): Drosophila melanogaster 
2014-04-02 | E-GEOD-49809 | biostudies-arrayexpress
TranscriptomicsEnhancer-core promoter specificity separates developmental and housekeeping regulation
Gene transcription in animals involves the assembly of the RNA polymerase II complex at core promoters and its cell type-specific activation by genomic enhancers that can be located more distally. However, how ubiquitous expression of housekeeping genes is achieved has remained less clear. In partic...
ORGANISM(S): Drosophila melanogaster 
2014-12-10 | E-GEOD-57876 | biostudies-arrayexpress
TranscriptomicsHormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin
Steroid hormones act as important developmental switches and their nuclear receptors regulate many genes. However, few hormone-dependent enhancers have been characterized and important aspects of their sequence architecture, cell type-specific activating and repressing functions, or the regulatory r...
ORGANISM(S): Drosophila melanogaster 
2014-03-27 | E-GEOD-47691 | biostudies-arrayexpress
UnknownEastern India Collaboration on Multisystem Inflammatory Syndrome in Children (EICOMISC): A Multicenter Observational Study of 134 Cases.
Not available
S-EPMC8963178 | biostudies-literature
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