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TranscriptomicsTranscription profiling of prCAD -/- mouse, a mouse model for retinal degeneration
This experiment was designed to identify transcripts that exhibit changes in abundance in the context of retinal degeneration by comparing transcript levels in adult wild type and prCAD -/- mouse retinas. Experiment Overall Design: Retinas were dissected from ~4 weeks old mice. Retinas from 3 prCA...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-10535 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice mutant for prCAD vs BALBC after dark adaption or retinal damage to investigate the genomic response to retinal disease and injury.
This SuperSeries is composed of the following subset Series:; GSE10528: The retinal transcriptional response to light damage; GSE10535: Retinal transcripts level alteration in the prCAD -/- mouse, a model for retinal degeneration Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-10577 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse BALBc albino retinas compared BETWEEN dark adapted AND light damaged animals
Transcriptional profiles were compared between dark adapted and light damaged BALBc (albino) mouse retinas. Experiment Overall Design: BALBc mice were dark adapted for one week. To produce light damage a subset of the mice were then exposed to 6,000 lux white fluorescent light for 6 hours. Retinas ...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-10528 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ark adapted and light damaged BALBc (albino) retinal pigmented epithelium
Transcriptional profiles were compared between dark adapted and light damaged BALBc (albino) mouse RPE. Experiment Overall Design: BALBc mice were dark adapted for one week. To produce light damage a subset of the mice were then exposed to 6,000 lux white fluorescent light for 1.5 hours. RPEs were c...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-13074 | biostudies-arrayexpress
TranscriptomicsEndothelin2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis
Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here we report that constitutive over-expression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell (EC) migration across the retinal surfac...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50059 | biostudies-arrayexpress
TranscriptomicsmRNA expression in HEK-293 /STF cells
Canonical Wnt signaling in endothelial cells (ECs) is required for vascularization of the central nervous system (CNS) and for formation and maintenance of barrier properties unique to CNS vasculature. Gpr124 is an orphan member of the adhesion G-protein-coupled receptor family that is expressed in ...
ORGANISM(S): Homo sapiens 
2014-08-20 | E-GEOD-60529 | biostudies-arrayexpress
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