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TranscriptomicsA conditionally immortalized human pancreatic beta cell line
Access to an unlimited number of human pancreatic beta cells represents a major challenge in the field of diabetes to better dissect human beta cell functions and to make significant progress in drug discovery and cell replacement therapies. We previously reported the generation of the EndoC-bH1 hum...
ORGANISM(S): Homo sapiens 
2014-03-21 | E-GEOD-48101 | biostudies-arrayexpress
Genomicsena-DATASET-ICL-01-03-2018-15:32:27:049-427 - samples
Whole Human Islet paired-ended RNA-seq of 64 human pancreatic donors.
EGAD00001003992 | EGA
GenomicsHuman Pancreatic Beta Cell lncRNAs Control Cell-Specific Regulatory Networks
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cel...
EGAS00001002865 | EGA
GenomicsImperial College London - Beta Cell Genome Regulation Lab
Data Access Committee EGAC00001000853
EGAC00001000853 | EGA
TranscriptomicsInsulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro
Expansion of beta cells from the limited number of adult human islet donors is an attractive prospect for increasing cell availability for cell therapy of diabetes. However, while evidence supports the replicative capacity of adult beta cells in vivo, attempts at expanding human islet cells in tissu...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-30732 | biostudies-arrayexpress
GenomicsPancreatic islet epigenomics reveals enhancer clusters that are enriched in Type 2 diabetes risk variants
We combined ChIP-seq of chromatin marks and key islet transcription factor with RNA-seq in human islets to map cis-regulatory networks in this primary tissue. The output of this project provides a reference map to dissect genetic variants that alter the susceptibility for Type 2 diabetes, and assist...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-MTAB-1919 | biostudies-arrayexpress
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