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ProteomicsMutant EGFR is a preferred SMURF2 substrate of ubiquitination: role in enhanced receptor stability and TKI sensitivity
We previously reported that differential protein degradation of TKI-sensitive [L858R, del(E746-A750)] and resistant (T790M) epidermal growth factor receptor (EGFR) mutants upon erlotinib treatment correlates with drug sensitivity. However, the molecular mechanism remains unclear. We also reported SM...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD018324 | Pride
Epidermal growth factor receptor (egfr)  smad ubiquitination regulatory factor 2 (smurf2)  ubiquitin conjugating enzyme h5 (ubch5)  protective ubiquitination  tyrosine kinase inhibitor (tki) resistance  lc-ms 
ProteomicsISGylation of H2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinoma
High expression of interferon-stimulated gene 15 (ISG15) has been associated with poor survival in patients with esophageal adenocarcinoma (EAC). Like ubiquitin, ISG15 utilizes its C-terminal LRGG motif to post-translationally modify target proteins through a process called ISGylation, thereby influ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD071548 | Pride
Radioresistance H2ax Esophageal adenocarcinoma. Homologous recombination repair (hrr) Isgylation 
UnknownEfficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degeneration: A Randomized, Double-blind, Multicenter, Placebo-Controlled Clinical Trial.
Not available
S-EPMC11880083 | biostudies-literature
TranscriptomicsTranscription profiling of mouse tumoros from cdc25a over-expressing animals - (MMTV-cdc25a;MMTV-neu and MMTV-neu
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4114 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of mouse cell lines MMTV-cdc25a;MMTV-neu murine cell line
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4767 | biostudies-arrayexpress
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