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UnknownMutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the β3-β4 loop to favor a low-affinity drug-binding state.
Not available
S-EPMC8503634 | biostudies-literature
ProteomicsStructure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
Akkermansia muciniphila, a mucin-degrading microbe found in the human gut, is often associated with positive health outcomes. The abundance of Akkermansia muciniphila is modulated by the presence and accessibility of nutrients, which can be derived from diet or host glycoproteins. In particular, the...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-06-09 | PXD032164 | Pride
X-ray crystallography Mucin Mucinase Microbiome O-glycosylation Molecular docking Enzyme structure Metalloprotease 
ProteomicsStructure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
Akkermansia muciniphila, a mucin-degrading microbe found in the human gut, is often associated with positive health outcomes. The abundance of Akkermansia muciniphila is modulated by the presence and accessibility of nutrients, which can be derived from diet or host glycoproteins. In particular, the...
ORGANISM(S): Homo sapiens (Human) 
2022-08-28 | PXD031225 | Pride
X-ray crystallography Mucin Mucinase Microbiome O-glycosylation Molecular docking Enzyme structure Metalloprotease 
UnknownNitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation.
Not available
S-EPMC2951232 | biostudies-literature
TranscriptomicsBulk RNA-seq of primary mouse neural progenitor cells derived from the embryonic neocortex or medial ganglionic eminence at different time points after exposure to ionizing radiation
Embryonic DNA damage, e.g. resulting from exposure to moderate and high doses of ionizing radiation, has important consequences on the normal neurodevelopment, often resulting in microcephaly that can be associated with seizures. The effects of prenatal radiation exposure have previously been invest...
ORGANISM(S): Mus musculus 
2025-10-01 | E-MTAB-14528 | biostudies-arrayexpress
UnknownStructural Characterization of Lithium and Sodium Bulky Bis(silyl)amide Complexes.
Not available
S-EPMC6100173 | biostudies-literature
TranscriptomicsS-adenosylmethionine (SAM) changes DNA methylation patterns in prostate cancer cells
Genome-wide DNA methylation profiling of human PC3 invasive prostate cancer cell line treated with vehicle control (SAH, S-adenosylhomocysteine) and with SAM (S-adenosylmethionine) as well as of untreated human LNCaP non-invasive prostate cancer cell line. The Illumina Infinium 450k Human DNA Methyl...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-62053 | biostudies-arrayexpress
UnknownMolecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins.
Not available
S-EPMC3113550 | biostudies-literature
Unknown2D Interfacial Crystallization Stabilized by Short-Chain Aliphatic Interfaces.
Not available
S-EPMC11948478 | biostudies-literature
UnknownGenetic Variant in ACVR2B Is Associated with Lean Mass.
Not available
S-EPMC4911281 | biostudies-literature
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