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ProteomicsAggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells
Proteostasis is maintained by optimum expression, folding, transport, and clearance of proteins. Deregulation of any of these processes triggers protein aggregation and is implicated in many age-related pathologies. Here, using quantitative proteomics and microscopy we show that aggregation of many ...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-28 | PXD012204 | Pride
Proteomics Proteostasis Mitochondrial respiratory chain complex Low complexity region Protein turnover Mitochondria Protein misfolding Protein aggregation 
ProteomicsNuclear-injuries by aberrant dynein-forces defeat proteostatic purposes of Lewy Body-like InclusionsNuclear-injuries by aberrant dynein-forces defeat proteostatic purposes of Lewy Body-like Inclusions
Biogenesis of inclusion bodies (IBs) facilitates protein quality control (PQC). Canonical aggresomes execute degradation of misfolded proteins while non-degradable amyloids quarantine into Insoluble Protein Deposits. Lewy Bodies (LBs) are well-known neurodegenerative IBs of α-Synuclein but PQC-benef...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-04-04 | PXD028941 | Pride
-synuclein Syn-aggresomes Nuclear envelope injury Inclusion bodies Lewy body Proteostasis over-saturation 
ProteomicsQUATERNARY AND QUINARY ORGANIZATION OF RESPIRATORY COMPLEX SUBUNITS TO ADAPT PROTEOSTASIS-STRESS
Phase separation and reversible aggregation of proteins is a well-recognized adaptive strategy to survive stress. Here, we show that RCC subunits are engaged into improved super-quaternary organizations inside mitochondria during proteostasis stress. Assembly and oligomeric organizations of Complex ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-04-04 | PXD014361 | Pride
Respiratory complex Supercomplex Proteasome inhibition Proteostasis stress Complexome profiling 
ProteomicsDistinct Stress Response to Mitochondrial Inter-membrane Space and Matrix Proteotoxic Stress are Preferentially Modulated by TOM complex and Vms1, respectively
Double-membrane-bound architecture of mitochondria is essential for its ATP synthesis function; simultaneously such structure sub-divides the organelle into inter-membrane space (IMS) and matrix. IMS and matrix are inherently different in protein folding milieu due to their contrasting oxido-reducti...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-07-09 | PXD027216 | Pride
Proteostasis Chaperones Mitochondrial unfolded protein response Proteotoxic stress Protein misfolding Stress response Ribosome quality control Vms1 
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