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TranscriptomicsTranscription profiling of CD8 T-cells predicts disease course in Crohn's disease and ulcerative colitis
The natural history of Crohn's disease (CD) and ulcerative colitis (UC) is variable. In patients with frequently-relapsing/steroid-refractory disease, sustained remission is more likely if immunomodulators are introduced earlier. However, many patients experience quiescent disease without immunomodu...
ORGANISM(S): Homo sapiens 
2011-07-19 | E-MTAB-331 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD8 T cells in systemic lupus erythematosus (SLE) and vasculitis
Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of the potentially toxic immunosuppressive therapy required for their control. Clinically useful biomarkers have been identified using DNA micr...
ORGANISM(S): Homo sapiens 
2010-06-02 | E-MTAB-157 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human separated leukocyte subsets in SLE and vasculitis
Objective: To optimize a strategy for identifying gene expression signatures differentiating SLE and anti-neutrophil cytoplasmic antibody-associated vasculitis that provide insight into the pathogenesis and identify biomarkers.
Methods: Forty four vasculitis patients, 13 SLE patients and 25 age...
ORGANISM(S): Homo sapiens 
2010-06-02 | E-MTAB-145 | biostudies-arrayexpress
GenomicsEGAS00001000490-sc-20130516 - samples
DNA methylation has been shown to play a major role in determining cellular phenotype by regulating gene expression. Moreover, dysregulation of differentially methylated genes has been implicated in disease pathogenesis of various conditions including cancer development as well as autoimmune disease...
EGAD00001000394 | EGA
GenomicsSequencing component for the whole genome methylation analysis in PBMCs and cell subsets pilot study
DNA methylation has been shown to play a major role in determining cellular phenotype by regulating gene expression. Moreover, dysregulation of differentially methylated genes has been implicated in disease pathogenesis of various conditions including cancer development as well as autoimmune disease...
EGAS00001000490 | EGA
GenomicsDAC for study Sequencing component for the whole genome methylation analysis in PBMCs and cell subsets pilot study 1733-sc-2013-
Data Access Committee EGAC00001000096
EGAC00001000096 | EGA
GenomicsMOLPAGE_data - samples
Case and control samples (Genotypes)
EGAD00010000371 | EGA
GenomicsMolecular Phenotyping to Accelerate Genomic Epidemiology (MolPAGE)
MolPAGE is an integrated EU project that aims to develop methods and tools for discovery of biomarkers associated with diabetes (see www.ocdem.ox.ac.uk for MolOBB and www.twinsuk.ac.uk for MolTWIN).
EGAS00000000102 | EGA
GenomicsMolPAGE Data Access Committee
Data Access Committee EGAC01000000017
EGAC01000000017 | EGA
GenomicsGoT2D: Genetics of Type 2 Diabetes, a study of the the genetic architecture of type 2 diabetes using low pass whole genome sequencing and high density SNP genotyping in 2,657 individuals.
The Genetics of Type 2 Diabetes Consortium (GoT2D) is a collaboration between the University of Michigan, the Broad Institute and the Wellcome Trust Centre for Human Genetics. The overall aim is to extend upon recent efforts, such as genome-wide association studies (GWAS) and large scale meta-analys...
EGAS00001001459 | EGA
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