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TranscriptomicsRBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs
Polyadenylation of mRNA precursors is mediated by a large multisubunit protein complex. Here we show that RBBP6 (retinoblastoma-binding protein 6), identified initially as an Rb- and p53-binding protein, is a component of this complex and functions in 3' processing in vitro and in vivo. RBBP6 associ...
ORGANISM(S): Homo sapiens 
2014-11-06 | E-GEOD-63036 | biostudies-arrayexpress
ProteomicsXL-MS of RBBP6-bound CPSF complex
The 3’ ends of almost all eukaryotic mRNAs are generated in an essential two-step processing reaction, endonucleolytic cleavage of an extended precursor followed by the addition of a poly(A) tail. By reconstituting the reaction from overproduced and purified proteins, we provide a minimal list of fo...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD031242 | Pride
Cpa 3' end Cpsf 
ProteomicsReconstitution of 3’-processing of mammalian pre-mRNA reveals a central role of RBBP6
The 3’ ends of almost all eukaryotic mRNAs are generated in an essential two-step processing reaction, endonucleolytic cleavage of an extended precursor followed by the addition of a poly(A) tail. By reconstituting the reaction from overproduced and purified proteins, we provide a minimal list of fo...
ORGANISM(S): Homo sapiens (Human) 
2022-03-04 | PXD031227 | Pride
Cpsf 3’-processing Xl-ms Rbbp6 
GenomicsRBBP6 anchors pre-mRNA 3’ end processing to nuclear speckles for efficient gene expression
RBBP6 anchors pre-mRNA 3’ end processing to nuclear speckles for efficient gene expression
PRJNA1082279 | ENA
GenomicsRBBP6 orchestrates diabetic endothelial dysfunction viadisrupting JUNB-centric chromatin topology
RBBP6 orchestrates diabetic endothelial dysfunction viadisrupting JUNB-centric chromatin topology
PRJNA1234557 | ENA
Genomics
RBBP6 knockdown experiment
PRJNA914900 | ENA
UnknownRBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation.
Not available
S-EPMC10951364 | biostudies-literature
UnknownProtein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.
Not available
S-EPMC6366944 | biostudies-literature
UnknownRBBP6 activates the pre-mRNA 3' end processing machinery in humans.
Not available
S-EPMC8887125 | biostudies-literature
TranscriptomicsRBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs
Polyadenylation of mRNA precursors is mediated by a large multisubunit protein complex. Here we show that RBBP6 (retinoblastoma-binding protein 6), identified initially as an Rb- and p53-binding protein, is a component of this complex and functions in 3' processing in vitro and in vivo. RBBP6 associ...
ORGANISM(S): Homo sapiens 
2014-11-06 | GSE63036 | GEO
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