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The Fanconi Anaemia (FA) pathway resolves replication fork-stalling inter-strand crosslinks (ICLs) and is mutated in Fanconi anaemia. FA is a rare recessive chromosomal instability syndrome, resulting in hypersensitivity to DNA-crosslinkers, and particularly disadvantageous for stem cell growth and ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-27 | PXD026545 | Pride
RBBP9 Suppresses Intestinal Inflammation and Inflammation-Induced Tumorigenesis by Regulating the JAK/STAT1 Pathway
we report a strategy for creating mechanism-based, light activated protease and hydrolase substrate traps in complex mixtures and live mammalian cells. The traps capture substrates of hydrolases, which normally use a serine or cysteine nucleophile. Replacing the catalytic nucleophile with geneticall...
ORGANISM(S): Homo sapiens (Human) 
2022-02-10 | PXD030381 | Pride
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