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ProteomicsInvasion preferences suggest a possible role for Plasmodium falciparum parasites in the expansion of Duffy negativity in West and Central Africa
Duffy antigen receptor for chemokines (DARC) is the primary red blood cell (RBC) receptor for invasion of human RBCs by Plasmodium vivax and Plasmodium knowlesi merozoites. By contrast, Plasmodium falciparum parasites, which are the dominant cause of malaria in West and Central Africa, use multiple ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD065766 | Pride
Plasma membrane profiling Rbc surface proteome Duffy-negative rbc surface proteome Tmt 
ProteomicsPhosphorylation Dependent Assembly of a 14-3-3 Anchored Signaling Complex During Erythrocyte Invasion by Plasmodium falciparum Merozoites
Red blood cell (RBC) invasion by Plasmodium merozoites requires multiple steps that are regulated by signalling pathways. However, the signalling pathways in merozoites that regulate microneme secretion and RBC invasion are not completely understood. Exposure of P. falciparum merozoites to a low pot...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-03-05 | PXD015093 | Pride
Lc ms-ms Malaria Rbc invasion 
TranscriptomicsTranscription profiling of synchronized Plasmodium falciparum cultures
The process of erythrocyte invasion by merozoites of Plasmodium falciparum involves multiple steps, including the formation of a moving junction characterized by the redundancy of many of the receptor-ligand interactions involved. Several of the parasite proteins that interact with erythrocyte recep...
ORGANISM(S): Plasmodium falciparum 
2007-11-26 | E-SGRP-9 | biostudies-arrayexpress
ProteomicsThe malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion
Red blood cell (RBC) invasion by malaria merozoites involves formation of a parasitophorous vacuole into which the parasite moves. The vacuole membrane then seals and pinches off behind the parasite through an unknown mechanism, enclosing it within the RBC. During invasion, several merozoite surface...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2020-11-27 | PXD021843 | Pride
Malaria Sub2 Protease Orbitrap 
UnknownRBC barcoding allows for the study of erythrocyte population dynamics and P. falciparum merozoite invasion.
Not available
S-EPMC4077748 | biostudies-literature
TranscriptomicsTranscriptome Analysis Reveal Molecular Targets of Erythrocyte Invasion Phenotype Diversity in Natural Plasmodium falciparum Isolates from Cameroon.
Further understanding of the molecular mediators of alternative RBC invasion phenotypes in endemic malaria parasites will support malaria blood stage vaccine or drug development. This study investigated the prevalence of SA-dependent and SA-independent RBC invasion pathways in endemic P. falciparum ...
ORGANISM(S): Plasmodium falciparum 
2025-01-22 | GSE264687 | GEO
GenomicsTranscriptome Analysis Reveal Molecular Targets of Erythrocyte Invasion Phenotype Diversity in Natural Plasmodium falciparum Isolates from Cameroon.
Transcriptome Analysis Reveal Molecular Targets of Erythrocyte Invasion Phenotype Diversity in Natural Plasmodium falciparum Isolates from Cameroon.
PRJNA1103802 | ENA
TranscriptomicsSingle-cell RNA sequencing of a 3D blood-brain-barrier model perfused with P. falciparum-infected red blood cells and egress products
This dataset consists of two individual sample-multiplexing (MULTI-seq) single-cell RNA sequencing experiments, MB10x01 and MB10x02. Single-cell RNA sequencing (10X Genomics) analyses were performed on a microfluidic 3D in vitro blood-brain-barrier model (containing primary human brain microvascular...
ORGANISM(S): Homo sapiens 
2025-06-25 | E-MTAB-14463 | biostudies-arrayexpress
UnknownRBC Membrane-Camouflaged Nanosystem-Mediated Synergistic Drug Combination for Enhanced Anti-Tumor Therapy.
Not available
S-EPMC12506840 | biostudies-literature
UnknownCD44 cross-linking promotes Plasmodium falciparum invasion.
Not available
S-EPMC12789465 | biostudies-literature
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