Transcription profiling of synchronized Plasmodium falciparum cultures

ABSTRACT: The process of erythrocyte invasion by merozoites of Plasmodium falciparum involves multiple steps, including the formation of a moving junction characterized by the redundancy of many of the receptor-ligand interactions involved. Several of the parasite proteins that interact with erythrocyte receptors or participate in other steps of the process of invasion are encoded by small subtelomerically-located multigene families of four to seven members. We report here that members of the multigene families pfRh, eba, rhopH1/clag and acbp exist in either an active or a silenced state. In the case of two members of the rhopH1/clag family, clag3.1 and clag3.2, expression was mutually exclusive. Silencing occurred in the absence of detectable DNA alterations, suggesting that it is transmitted epige

ORGANISM(S): Plasmodium falciparum

SUBMITTER: Celine Carret 

PROVIDER: E-SGRP-9 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress