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MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
ProteomicsReactive astrocytes in ALS display dysregulated intron retention
Reactive astrocytes are implicated in amyotrophic lateral sclerosis (ALS), although the mechanisms controlling reactive transformation are unknown. We show that decreased intron retention (IR) is common to human iPSC-derived astrocytes carrying VCP, C9orf72 and SOD1 ALS-causing mutations as well as ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022604 | Pride
Alternative splicing Astrocytes Transcriptome profiling Amyotrophic lateral sclerosis Intron retention Motor neuron disease Neurodegeneration Reactive astrocytes Human induced pluripotent stem cell Rna sequencing 
TranscriptomicsAcutely isolated murine cortical astrocytes and microglia: Alzheimer's disease vs wildtype- effect of gfap-/- and vim-/-
GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease. Reactive astrocytes with an increased expression of intermediate filament (IF) proteins Glial Fibrillary...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74614 | biostudies-arrayexpress
GenomicsTranscriptome analysis of senescent and reactive human fetal astrocytes
Transcriptome analysis of senescent and reactive human fetal astrocytes
PRJNA523186 | ENA
ProteomicsSTAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
The brain microenvironment imposes a particularly intense selective pressure on metastasis initiating cells, but successful metastasis bypass this control through mechanisms that are poorly understood. Reactive astrocytes are key components of this microenvironment, as they have been observed to con...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-16 | PXD008956 | Pride
Astrocytes Brain metastasis Stat3 Secretome 
GenomicsReactive astrocytes in ALS models display dysregulated intron retention
Reactive astrocytes in ALS models display dysregulated intron retention
PRJNA672040 | ENA
GenomicsExosome-transmitted RVT1 from reactive astrocytes promotes recurrence glioblastoma proliferation
Exosome-transmitted RVT1 from reactive astrocytes promotes recurrence glioblastoma proliferation
PRJNA475107 | ENA
GenomicsReactive human iPSC astrocytes suppress oligodendrocyte precursor cell differentiation
Reactive human iPSC astrocytes suppress oligodendrocyte precursor cell differentiation
PRJNA805526 | ENA
GenomicsLipid-accumulated reactive astrocytes promote seizure activity in epilepsy [mouse]
Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [mouse]
PRJNA808397 | ENA
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