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TranscriptomicsCiliary neurotrophic factor induces genes associated with inflammatory response and gliosis in the retina: A gene profiling study of flow-sorted, Muller (glial) cells
Our data suggest that CNTF remodels the transcription profile of Muller (glial) cells leading to induction of networks associated with transcription, cell cycle regulation and inflammatory response. CNTF also appears to function as an inducer of gliosis in the retina. These studies provide new insig...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-27195 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse optic nerve head after optic nerve crush
Reactive gliosis is a complex process that involves profound changes in gene expression. We used microarray to indentify differentially expressed genes and to investigate the molecular mechanisms of reactive gliosis in optic nerve head in response to optic nerve crush injury. C57Bl/6 female mice wer...
ORGANISM(S): Mus musculus 
2013-07-15 | E-GEOD-40857 | biostudies-arrayexpress
GenomicsBrillouin Microscopic Assessment of Retinal Stiffness During Reactive Müller Gliosis
Brillouin Microscopic Assessment of Retinal Stiffness During Reactive Müller Gliosis
PRJNA1290320 | ENA
GenomicsAutism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [ATAC-seq]
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [ATAC-seq]
PRJNA1132699 | ENA
GenomicsAutism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [bulk RNA-seq]
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [bulk RNA-seq]
PRJNA1132694 | ENA
GenomicsAutism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [Microglia RNA-seq]
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [Microglia RNA-seq]
PRJNA1132698 | ENA
GenomicsGpr37 contributes to inflammation-induced GI dysmotility by regulating enteric reactive gliosis.
Gpr37 contributes to inflammation-induced GI dysmotility by regulating enteric reactive gliosis.
PRJNA1091683 | ENA
TranscriptomicsBrillouin Microscopic Assessment of Retinal Stiffness During Reactive Müller Gliosis
Increased retinal stiffness can indicate reactive gliosis, fibrosis, or ECM remodeling – all hallmarks of early retinal damage due to diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy. Here, we demonstrate that Brillouin microscopy can detect increased stiff...
ORGANISM(S): Mus musculus 
2026-02-23 | GSE302395 | GEO
GenomicsAutism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [ATAC-seq]
Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help understand brain pathophysiology and improve outcomes. Here, we report that adult ablation of the ASD-associated CHD8 in astrocyt...
ORGANISM(S): Mus musculus 
2024-07-09 | GSE271652 | GEO
TranscriptomicsAutism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [Microglia RNA-seq]
Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help understand brain pathophysiology and improve outcomes. Here, we report that adult ablation of the ASD-associated CHD8 in astrocyt...
ORGANISM(S): Mus musculus 
2024-07-09 | GSE271651 | GEO
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