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ProteomicsTyrosine-1 of RNA polymerase II CTD controls global termination of gene transcription in mammals
The aim of the project was to analyse the functional role of Tyrosine-1 of mammalian RNA polymerase II CTD in the regulation of transcription-coupled processes. We studied mammalian CTD mutants to analyze the function of tyrosine1 residues. Mutation of 3/4 of the tyrosine residues in a mutant YFFF ...
ORGANISM(S): Homo sapiens (Human) 
2018-01-09 | PXD008270 | Pride
Tyrosine1 Transcription termination Promoter-proximal pausing Read-through transcription Divergent transcription. Ctd Rna polymerase ii 
GenomicsCPSF73 activation and 3’ Pol II pausing are lost during read-through transcription after heat shock [RNA-seq]
CPSF73 activation and 3’ Pol II pausing are lost during read-through transcription after heat shock [RNA-seq]
PRJNA1297775 | ENA
GenomicsCPSF73 activation and 3’ Pol II pausing are lost during read-through transcription after heat shock [ChIP-seq]
CPSF73 activation and 3’ Pol II pausing are lost during read-through transcription after heat shock [ChIP-seq]
PRJNA1297774 | ENA
TranscriptomicsGlucosylated hydroxymethyluracil (DNA base J) prevents transcriptional read-through in Leishmania
Some T's in nuclear DNA of trypanosomes and Leishmania are hydroxylated and glucosylated to yield base J (?-D-glucosyl-hydroxymethyluracil). In Leishmania about 99% of J is located in telomeric repeats. We show here that most of the remaining J is located at chromosome-internal RNA Polymerase II ter...
ORGANISM(S): Leishmania major 
2011-10-15 | E-GEOD-32976 | biostudies-arrayexpress
UnknownPervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma.
Not available
S-EPMC4744188 | biostudies-literature
TranscriptomicsPervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma
Aberrant expression of cancer genes and non-canonical RNA species is a hallmark of cancer. However, the mechanisms driving such atypical gene expression programs are incompletely understood. Here, our transcriptional profiling of a cohort of 50 primary clear cell renal cell carcinoma (ccRCC) samples...
ORGANISM(S): Homo sapiens 
2015-11-17 | GSE64451 | GEO
GenomicsGlucosylated hydroxymethyluracil (DNA base J) prevents transcriptional read-through in Leishmania
Glucosylated hydroxymethyluracil (DNA base J) prevents transcriptional read-through in Leishmania
PRJNA146423 | ENA
GenomicsCPSF73 activation and 3’ Pol II pausing are lost during read-through transcription after heat shock [ChIP-seq]
Multiple types of cellular stress induce RNA polymerase II (Pol II) to read through normal termination sites at mRNA genes, causing long downstream regions to be transcribed. We observed strong read-through transcription downstream of thousands of genes after heat shock. Additionally, the 3’ Pol II ...
ORGANISM(S): Homo sapiens 
2026-02-04 | GSE303857 | GEO
TranscriptomicsCPSF73 activation and 3’ Pol II pausing are lost during read-through transcription after heat shock [RNA-seq]
Multiple types of cellular stress induce RNA polymerase II (Pol II) to read through normal termination sites at mRNA genes, causing long downstream regions to be transcribed. We observed strong read-through transcription downstream of thousands of genes after heat shock. Additionally, the 3’ Pol II ...
ORGANISM(S): Homo sapiens 
2026-02-04 | GSE303856 | GEO
Unknown'Read-through marking' reveals differential nucleotide composition of read-through and truncated cDNAs in iCLIP.
Not available
S-EPMC6051193 | biostudies-literature
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