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The aim of the project was to analyse the functional role of Tyrosine-1 of mammalian RNA polymerase II CTD in the regulation of transcription-coupled processes. We studied mammalian CTD mutants to analyze the function of tyrosine1 residues. Mutation of 3/4 of the tyrosine residues in a mutant YFFF ...
ORGANISM(S): Homo sapiens (Human) 
2018-01-09 | PXD008270 | Pride
The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is composed of a repetition of YSPTSPS heptads and functions as a loading platform for protein complexes that regulate transcription, splicing and maturation of RNAs. Here, we studied mammalian CTD mutants to analyze the function of tyrosi...
ORGANISM(S): Homo sapiens 
2017-12-29 | GSE94330 | GEO
Tyrosine-1 of RNAPII CTD controls global termination of gene transcription in mammals
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