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ProteomicsSecretome analysis of human A549 Lung cancer cells harboring LKB1 mutations.
STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation. Elucidating the contribution of somatic mutations to cancer is essential for personalized medicine. STK11 (LKB1) tumor suppressor appears to be inactivated in human cancer, however, somatic missense mutati...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018041 | Pride
Human  lung cancer  lkb1  lc-msms  secretome 
ProteomicsBRAF activation by metabolic stress promotes glycolysis and survival, sensitizing NRASQ61 mutated melanomas to targeted therapy.
NRAS-mutated melanoma lacks an approved first-line treatment. Metabolic reprogramming is considered a novel target to control cancer; however, it is mostly unknow how the NRAS oncogene contributes to this cancer hallmark. Here, we show that NRASQ61-mutated melanomas harbor specific metabolic alterat...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD028297 | Pride
Melanoma  braf  nras mutation  metabolic stress  pfkfb2 
UnknownTakayasu's arteritis causing coronary stenosis with myocardial ischemia, severe aortic regurgitation, and pericarditis.
Not available
S-EPMC11609549 | biostudies-literature
UnknownComplex multiple risk intervention to promote healthy behaviours in people between 45 to 75 years attended in primary health care (EIRA study): study protocol for a hybrid trial.
Not available
S-EPMC6045838 | biostudies-literature
UnknownEDUCORE project: a clinical trial, randomised by clusters, to assess the effect of a visual learning method on blood pressure control in the primary healthcare setting.
Not available
S-EPMC2920281 | biostudies-literature
UnknownRole of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential.
Not available
S-EPMC12911659 | biostudies-literature
UnknownAcute kidney injury in critical ill patients affected by influenza A (H1N1) virus infection.
Not available
S-EPMC3221999 | biostudies-literature
UnknownMachine-learning analysis identifies "elite" viral controllers with increased survival and homeostatic responses in critical COVID-19.
Not available
S-EPMC12031886 | biostudies-literature
UnknownEffectiveness of an intensive E-mail based intervention in smoking cessation (TABATIC study): study protocol for a randomized controlled trial.
Not available
S-EPMC3648415 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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