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ProteomicsIsolation and MS characterisation of recombinant human septin octameric complexes containing distinct SEPT9 isoforms
Native human septins form heterooctameric complexes containing different SEPT9 isoforms. To enable studies of SEPT9 function, we established a protocol for the isolation of recombinant human octamers harboring distinct SEPT9 isoforms. Mass spectrometry analysis is used to assess the purity, integrit...
ORGANISM(S): Homo sapiens (Human) 
2021-07-27 | PXD023857 | Pride
Human septins Lc-msms Recombinant septin complex Sept9 
UnknownDrosophila Orc6 facilitates GTPase activity and filament formation of the septin complex.
Not available
S-EPMC2613121 | biostudies-literature
UnknownProduction and analysis of a mammalian septin hetero-octamer complex.
Not available
S-EPMC7845785 | biostudies-literature
UnknownSeptin-3 autoimmunity in patients with paraneoplastic cerebellar ataxia.
Not available
S-EPMC10061979 | biostudies-literature
UnknownBiochemical Characterization of a Human Septin Octamer.
Not available
S-EPMC8928218 | biostudies-literature
TranscriptomicsTranscription profiling of BXH/HXB rat recombinant inbred strains derived from the spontaneously hypertensive rat (SHR/Ola) and the Brown Norway congenic strains carrying the polydactylyl-luxate mutation (BN-Lx)
BXH/HXB rat recombinant inbred (RI) strains are derived from the spontaneously hypertensive rat (SHR/Ola) and the Brown Norway congenic strains carrying the polydactylyl-luxate mutation (BN-Lx). Tissue from the apex of left ventricle of the heart was disected from 128 RI SHR/Ola and BN-Lx parental s...
ORGANISM(S): Rattus norvegicus 
2008-04-01 | E-MIMR-222 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human response to etanercept treatment in patients with Psoriasis
The success of TNF inhibitors for treatment of psoriasis and other inflammatory diseases was previously attributed to blockade of innate immunity. In a clinical trial using etanercept TNF blocking agent to treat psoriasis vulgaris, we used affymetrix gene arrays to analyze broad gene profiles in le...
ORGANISM(S): Homo sapiens 
2009-11-09 | E-GEOD-11903 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse embryonic stem cells expressing the transcription factor NGN3 for 12 hours, 24 hours and 48 hours
A mouse embryonic stem cell line was generated which stably expressed the ngn3 transcription factor under the control of the Tet-On inducible system using knock-ins in the ROSA26 and the HPRT loci. The undifferentiated mouse embryonic stem cells were then differentiated into Embryoid Bodies in suspe...
ORGANISM(S): Mus musculus 
2007-09-01 | E-MIMR-461 | biostudies-arrayexpress
TranscriptomicsGene profiling within the orexin-producing neurons
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and attacks of muscle atonia triggered by strong emotions (cataplexy). The best biological marker of narcolepsy is orexin deficiency with dramatic loss in hypothalamic orexin-producing neurons. Together with a tight HLA and...
ORGANISM(S): Mus musculus 
2010-02-24 | E-GEOD-17617 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse finally differentiated 3T3-L1 adipocytes treated with insulin (0 or 100nM)or metformin (0 or 2mM)for 2 and 12 hours
Finally differentiated 3T3-L1 adipocytes are treated with insulin (0 or 100nM)or metformin (0 or 2mM)for 2 and 12 hours to understand insulin and metformin(an anti-diabetic drug commonly applied for Non-Insulin Dependent Diabetes Mellitus)action in adipose tissues.
ORGANISM(S): Mus musculus 
2013-01-30 | E-BAIR-8 | biostudies-arrayexpress
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