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GenomicsGenome wide profiling of RNA Polymerase II upon knock-down or overexpression of RECQL5
RECQL5 globally effects the distribution of RNA Polymerase II on genes in a dose dependent manner. Knock-down of RECQL5 reduces RNA Polymerase II density in the gene body, while increasing density on TSS and TTS. Overexpression shows exactly the opposite effect. We postulate that RECQL5 acts as a...
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-49008 | biostudies-arrayexpress
ProteomicsRECQL5 and transcription-coupled DNA repair complex coordinate to regulate transcription elongation
The RECQL5 helicase is crucial for maintaining genome stability and functions at the intersection of transcription, replication, and DNA repair. RECQL5 associates with RNA15 polymerase II (Pol II) to modulate transcription elongation, yet the underlying mechanism remains unclear. Here, we report cry...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD062042 | Pride
Recql5 Transcription Crosslinking 
TranscriptomicsMapping of nascent RNA upon release of DRB in WT and KD of RECQL5
Global Run-On has been performed on WT or KD for RECQL5 cells after release from DRB. When RECQL5 is knocked-down the transcriptional wave front is more advanced, suggesting that transcription is faster. Constitutive knock-down cell lines expressing or not endogenous levels of shRNA resistant RECQL...
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-49133 | biostudies-arrayexpress
GenomicsRECQL5 Controls Transcript Elongation and Suppresses Transcription-Associated Genome Instability
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-49134 | biostudies-arrayexpress
GenomicsExpression data from Saccharomyces cerevisiae strains expressing human RECQL5 helicase
Expression data from Saccharomyces cerevisiae strains expressing human RECQL5 helicase
PRJNA746581 | ENA
GenomicsHuman helicase RECQL5-Flag ChIP DNA from Saccharomyces cerevisiae strain W303-1AR5, asynchronous culture
Human helicase RECQL5-Flag ChIP DNA from Saccharomyces cerevisiae strain W303-1AR5, asynchronous culture
PRJNA746579 | ENA
TranscriptomicsExpression data from Saccharomyces cerevisiae strains expressing human RECQL5 helicase
We expressed human RECQL5 in the model organism Sacharomyces cerevisiae. We found that RECQL5 overexpression in yeast leads to cell growth inhibition and increased genotoxic sensitivity. We carried-out transcriptome analysis of yeast strains overexpressing human RECQL5 helicase to explore its impact...
ORGANISM(S): Saccharomyces cerevisiae Schizosaccharomyces pombe 
2025-01-15 | GSE180112 | GEO
GenomicsHuman helicase RECQL5-Flag ChIP DNA from Saccharomyces cerevisiae strain W303-1AR5, asynchronous culture
We expressed human RECQL5 in the yeast model Sacharomyces cerevisiae. Being RECQL5 the only member of the family shown to interact with the RNA polymerase II we explored the recruitment of RECQL5 to chromatin. Data reveal a genome wide recruitment of RECQL5 at actively transcribed regions that incre...
ORGANISM(S): Saccharomyces cerevisiae 
2025-01-15 | GSE180107 | GEO
UnknownAltered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.
Not available
S-EPMC5342802 | biostudies-literature
GenomicsGenome wide profiling of RNA Polymerase II upon knock-down or overexpression of RECQL5
RECQL5 globally effects the distribution of RNA Polymerase II on genes in a dose dependent manner. Knock-down of RECQL5 reduces RNA Polymerase II density in the gene body, while increasing density on TSS and TTS. Overexpression shows exactly the opposite effect. We postulate that RECQL5 acts as a re...
ORGANISM(S): Homo sapiens 
2014-06-09 | GSE49008 | GEO
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