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ProteomicsAging-triggered iron-rich insoluble protein aggregates in the spleen originate chiefly from red pulp macrophages.
Both iron homeostasis and erythropoiesis are known to be affected by aging. Iron needs in mammals are met primarily by iron recycling from senescent red blood cells (RBCs), a task chiefly accomplished by red pulp macrophages (RPMs) in the spleen. Given that RPMs continuously process iron, their cell...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-02 | PXD038660 | Pride
Iron-rich protein aggregates Iron-dextran injection Mouse Red pulp macrophages Spleen 
GenomicsTissue printing: splenic red pulp macrophages of once-malaria infected mice are transcriptionally identical to prenatally seeded red pulp macrophages from uninfected mice.
Tissue printing: splenic red pulp macrophages of once-malaria infected mice are transcriptionally identical to prenatally seeded red pulp macrophages from uninfected mice.
PRJNA630449 | ENA
GenomicsElucidating the mechanism underlying sepsis- induced hemolysis, RNA_seq of red pulp macrophages
Elucidating the mechanism underlying sepsis- induced hemolysis, RNA_seq of red pulp macrophages
PRJNA1454521 | ENA
TranscriptomicsTissue printing: splenic red pulp macrophages of once-malaria infected mice are transcriptionally identical to prenatally seeded red pulp macrophages from uninfected mice.
Acute malaria infection with P. chabaudi obliterates embryonically seeded tissue-resident red pulp macrophages in the spleen of C57Bl/6J mice - regardless of whether the infection is mild (mosquito transmitted P. chabaudi AS - no hyperparasitaemia, no measurable clinical manifestations of disease ot...
ORGANISM(S): Mus musculus 
2020-11-26 | GSE149894 | GEO
GenomicsPPARγ is essential for the development of erythroblastic island macrophages and red pulp macrophages
PPARγ is essential for the development of erythroblastic island macrophages and red pulp macrophages
PRJNA699241 | ENA
TranscriptomicsTranscript profiling in splenic red pulp macrophages from SIRPa-KO mice and WT mice
To compare the splenic macrophages between SIRPα-knockout mice and WT mice, we performed a complete transcript profiling of the splenic red pulp macrophages from SIRPα-KO mice compared to WT mice using mRNA microarray as a discovery platform. SIRPα-KO mice and WT mice were kept under the same condit...
ORGANISM(S): Mus musculus 
2016-11-22 | GSE78191 | GEO
TranscriptomicsElucidating the mechanism underlying sepsis- induced hemolysis, RNA_seq of red pulp macrophages
An RNA-seq of red pulp macrophages 2 hours after CLP or sham to investigate differenial gene expression and functional effects.
ORGANISM(S): Mus musculus 
2026-08-01 | GSE328303 | GEO
TranscriptomicsTranscription profiling of various mouse cell types
RNA from various murine cell types were harvested for gene expression profiling.
ORGANISM(S): Mus musculus 
2008-11-01 | E-MEXP-1802 | biostudies-arrayexpress
TranscriptomicsPPARγ is essential for the development of erythroblastic island macrophages and red pulp macrophages
Macrophages in the bone marrow erythroblastic island (EIM) and splenic red pulp (RPM) are required for terminal erythropoiesis and removal of aged erythrocytes, respectively. This manuscript shows that EIM and RPM development require both PPARg and Spi-C.
ORGANISM(S): Mus musculus 
2021-02-04 | GSE166085 | GEO
TranscriptomicsThe role of IL-33 on red pulp macrophage (RPM) development
This study investigated the effects of IL1RL1 deficiency on the devlopment of red pulp macrophages (RPM)
ORGANISM(S): Mus musculus 
2020-03-11 | GSE146782 | GEO
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