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Proteomicsstudy of actin interactome in Alzheimers disease mouse model
Filamentous actin (F-actin) is one of the major cytoskeleton proteins present in dendritic spines and it is an essential component for defining dendritic spine morphology. We have shown that synaptosomal F-actin levels were significantly decreased in APP/PS1 mice as early as one month of age. The mo...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050802 | Pride
F-actin loss Alzheimers disease Synapse 
UnknownThe M/V X-Press Pearl Nurdle Spill: Contamination of Burnt Plastic and Unburnt Nurdles along Sri Lanka's Beaches.
Not available
S-EPMC10114858 | biostudies-literature
UnknownRectifying calibration error of Goldmann applanation tonometer is easy!
Not available
S-EPMC4290199 | biostudies-literature
GenomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma (ChIP-Seq)
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression. Here, we demonstrate that CBP/EP300 bromodomain inhibition preferentially abrogates the viability of multiple mye...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71909 | biostudies-arrayexpress
TranscriptomicsExpression Profile of Embryonic Stem Cell Derived Serotonin Neurons
The rhesus embryonic stem cell line 366.4 differentiates into serotonin neurons. RNA was extracted from ESC colonies, embryoid body (Ebs), Neurospheres in selection (N1), Proliferating serotonin neurons (N2) and differentiating serotonin neurons (N3). RNA was labeled with Enzo biotin labelling kit a...
ORGANISM(S): Macaca mulatta 
2010-04-08 | E-GEOD-16168 | biostudies-arrayexpress
TranscriptomicsTranscriptomics of Axillary Bud Outgrowth Regulation by Shade Signals in Arabidopsis
Aims: To determine the changes in the Arabidopsis axillary bud transcriptome in response to changes in the red light (R) to far red light (FR) ratio (R:FR). Background: The branching habit of plants is a key determinant of overall plant form and function with great relevance to modern agriculture. S...
ORGANISM(S): Arabidopsis thaliana 
2012-11-21 | E-GEOD-42415 | biostudies-arrayexpress
UnknownInhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies.
Not available
S-EPMC2910694 | biostudies-literature
TranscriptomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71911 | biostudies-arrayexpress
TranscriptomicsPrediction of gene activity based on an integrated multi-omics approach.
An increasingly common method for predicting gene activity is genome-wide chromatin immunoprecipitation of M-bM-^@M-^XactiveM-bM-^@M-^Y chromatin modifications followed by massively parallel sequencing (ChIP-seq). Using a novel ChIP-seq quantification method (cRPKM), we tested the power of such ChIP...
ORGANISM(S): Mus musculus 
2013-11-19 | E-GEOD-52450 | biostudies-arrayexpress
UnknownPrognostic significance of extramedullary disease (EMD) detected on pre-transplant <sup>18</sup>F-FDG PET/CT in patients with multiple myeloma: Results of PIPET-M trial.
Not available
S-EPMC10654356 | biostudies-literature
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