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ProteomicsRetina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Net-works after Optic Nerve Crush in a Rat Model of Surgical Menopause. Katalin Prokai-Tatrai, Khadiza Zaman, Ammar Kapic, Kelleigh Hogan , Gabriela Sanchez-Rodriguez, Anna E. Silverio Vien Nguyen , Laszlo Prokai and Andrew J. Feola
The association between 17β-estradiol (E2) deprivation, seen in menopause and a risk for devel-oping glaucoma, has been shown. Thus, exogenous supplementation of E2 may protect against retinal ganglion cell (RGC) degradation and vision loss. Here, we investigated the utility of topical 10β,17β-dihyd...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-07 | PXD059520 | Pride
Bioinformatics  dhed  estrogen  glaucoma  menopause  optic nerve crush  optomotor response  protein–protein interaction networks  quantitative label-free retina proteomics 
UnknownWhat's next in cancer immunotherapy? - The promise and challenges of neoantigen vaccination.
The process of tumorigenesis leaves a series of indelible genetic changes in tumor cells, that when expressed, have the potential to be tumor-specific immune targets. Neoantigen vaccines that capitalize on this potential immunogenicity have shown efficacy in preclinical models and have now entered c...
S-EPMC8855878 | biostudies-literature
UnknownFusion transcript discovery in formalin-fixed paraffin-embedded human breast cancer tissues reveals a link to tumor progression.
The identification of gene fusions promises to play an important role in personalized cancer treatment decisions. Many rare gene fusion events have been identified in fresh frozen solid tumors from common cancers employing next-generation sequencing technology. However the ability to detect transcri...
S-EPMC3984112 | biostudies-literature
UnknownThe 17-Gene Genomic Prostate Score Assay Is Prognostic for Biochemical Failure in Men With Localized Prostate Cancer After Radiation Therapy at a Community Cancer Center.

Purpose

The objective of this study was to assess the association between the Oncotype DX Genomic Prostate Score (GPS) assay and long-term outcomes in men with localized prostate cancer (PCa) after radiation therapy (RT). We hypothesized that the GPS assay is prognostic for biochemical failu...
S-EPMC10157115 | biostudies-literature
UnknownSpecific down-regulation of an engineered human cyclin D1 promoter by a novel DNA-binding ligand in intact cells.
Cyclin D1 is expressed at abnormally high levels in many cancers and has been specifically implicated in the development of breast cancer. In this report we have extensively analyzed the cyclin D1 promoter in a variety of cancer cell lines that overexpress the protein and identified two critical reg...
S-EPMC30392 | biostudies-literature
UnknownExploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples.
Not available
S-EPMC8720242 | biostudies-literature
UnknownNew epitopes in ovalbumin provide insights for cancer neoepitopes.
MHC I-restricted epitopes of chicken ovalbumin (OVA) were originally identified using CD8 T cells as probes. Here, using bioinformatics tools, we identify four additional epitopes in OVA in addition to a cryptic epitope. Each new epitope is presented in vivo, as deduced from the lack of CD8 response...
S-EPMC6538383 | biostudies-literature
UnknownPhase I trial of anti-CS1 monoclonal antibody elotuzumab in combination with bortezomib in the treatment of relapsed/refractory multiple myeloma.

Purpose

To evaluate the maximum-tolerated dose (MTD), safety, and efficacy of elotuzumab in combination with bortezomib in patients with relapsed or relapsed and refractory multiple myeloma (MM).

Patients and methods

Elotuzumab (2.5, 5.0, 10, or 20 mg/kg intravenously [IV]) and bortez...
S-EPMC4874204 | biostudies-literature
ProteomicsIdentification of biomarkers for PKD1 using urinary exosomes
Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD. Affected individuals inherit a defective copy of either the PKD1 or PKD2 gene, encoding the proteins polycystin?1 (PC1) or polycystin?2 (PC2) respectively. PC1 and PC2 are secreted on urinary exosome?like vesicles (ELVs)...
ORGANISM(S): Homo sapiens (Human) 
2014-12-02 | PXD001075 | Pride
Exosomes Exosome-like vesicles Pkd Adpkd Autosomal dominant polycystic kidney disease Urine 
UnknownPreclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
The monoclonal antibodies ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) have shown remarkable antitumor activity in an increasing number of cancers. When combined, ipilimumab and nivolumab have demonstrated superior activity in patients with metastatic melanoma (CHECKMATE-067). Here we describe...
S-EPMC5017747 | biostudies-literature
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