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ProteomicsFull geroprotection from brief rapamycin treatment by persistently increased intestinal autophagy
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid the adverse side-effects of clinical dosing regimes. Here we show a profound memory effect of brief rapamycin treatment. Brief, early adult treatment extended lifespan in Drosophila to the same...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-07-18 | PXD020820 | Pride
Autophagy Fly Tmt Lifespan Drosophila Rapamycin 
TranscriptomicsIntestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
We identified that Drosophila FoxA transcription Fork Head (FKH) function is necessary for reduced insulin signalling and rapamycin induced longevity. Furthermore, we determined that FKH function in the gut tissue alone is sufficient to extend lifespan. We carried out RNA-sequencing in gut tissue o...
ORGANISM(S): Drosophila melanogaster 
2017-09-23 | E-MTAB-6056 | biostudies-arrayexpress
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