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This study represents the first attempt to characterize the RNA chaperone Hfq regulon in bacterial pathogen using an integrative omics approach. Gene expression profiles were analyzed by RNA-seq and protein amounts in cell-associated and cell-free fractions were determined by LC-MS/MS technique. Com...
ORGANISM(S): Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2019-07-02 | PXD013953 | Pride
The QstR regulon of Vibrio cholerae
Pseudomonas aeruginosa displays tremendous metabolic diversity, controlled in part by the abundance of transcription regulators in the genome. We have been investigating P. aeruginosaM-bM-^@M-^Ys response to the host, particularly changes regulated by the host-derived quaternary amines choline and g...
ORGANISM(S): Pseudomonas aeruginosa 
In Mycobacterium tuberculosis, the sensor kinases DosT and DosS activate the transcriptional regulator DosR, resulting in the induction of the DosR regulon, important for anaerobic survival and perhaps latent infection. The individual and collective roles of these sensors has been postulated biochem...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
The experimental design was to determine the regulon of the transcriptional activator RarA. This was done by comparing the transcriptome profiles between a rarA overexpressor and the baseline control. RarA overexpression was achieved by plasmid mediated overexpression of the rarA gene and the baseli...
ORGANISM(S): Klebsiella pneumoniae 
The TyrR regulon of Enterobacter ludwigii UW5
Transcriptional profiling of Helicobacter pylori comparing 26695 wild-type strain and a HP0244-deficient mutant 26695/∆HP0244::km treated at three different pH conditions (pH 7.4, pH 4.5 without urea, or pH 2.5 with 30 mM urea) for 30 min to define the HP0244 acid-responsive regulon Keywords: Gen...
ORGANISM(S): Helicobacter pylori 
Post-transcriptional regulons coordinate the expression of groups of genes in eukaryotic cells, yet relatively few have been characterised. Parasitic trypanosomatids are particularly good models for studies on such mechanisms because they exhibit almost exclusive polycistronic, and unregulated, tran...
ORGANISM(S): Trypanosoma brucei 
2019-11-13 | PXD012450 | Pride
RNA-seq of strains grown under the control of native galactose regulon or synthetic xylose regulon vs constitutive expression of galactose and xylose metabolic genes
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