Sort   by:  
 Page size 
TranscriptomicsCpG island methylation in colorectal cancer
To globally define methylation-M-bM-^@M-^YproneM-bM-^@M-^Y and -M-bM-^@M-^YprotectedM-bM-^@M-^Y CpG islands in cancer, we analyzed the methylation status of 23,000 CpG islands of the human genome in 19 colorectal carcinoma samples as well as normal colon using our previously described methyl-CpG imm...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-25221 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in colorectal carcinoma samples compared to normal human colon
To globally define methylation-’prone’ and -’protected’ CpG islands in colorectal carcinoma we analyzed the methylation status of 23,000 CpG islands of the human genome in ten coleorectal carcinoma samples as well as normal colon using our previously described methyl-CpG immunoprecipitation ...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17512 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in acute leukemia samples compared to normal human monocytes
To globally define methylation-’prone’ and -’protected’ CpG islands in leukemia, we analyzed the methylation status of 23,000 CpG islands of the human genome in eight acute leukemia samples as well as normal blood monocytes using our previously described methyl-CpG immunoprecipitation (MCIp)...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17510 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in AML cell lines compared to normal human monocytes
To globally define methylation-’prone’ and -’protected’ CpG islands in leukemia, we analyzed the methylation status of 23,000 CpG islands of the human genome in two acute leukemia cell lines as well as normal blood monocytes using our previously described methyl-CpG immunoprecipitation (MCIp...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17455 | biostudies-arrayexpress
GenomicsMechanisms of PU.1 binding site selection in-vivo
The majority of sequence-specific transcription factors bind genomic DNA only at a fraction of their potential binding sites and the ‘rules’ for binding or not-binding are only partially understood. Here, we studied the binding properties of the myeloid and B-cell specific transcription factor PU.1 ...
ORGANISM(S): Homo sapiens 
2013-05-15 | E-GEOD-43098 | biostudies-arrayexpress
TranscriptomicsIL-4-primed bone marrow macrophages isolated from C57Bl6/J or Balb/cAnNCrl mice
To compare the expression profile of differentiated mouse bone marrow macrophages (BMM) in response to IL-4, we have employed whole genome microarray expression profiling. For this purpose, bone marrow cells were isolated from 8 to 12 weeks old C57BL6/J and Balb/cAnNCrl mice and cultured in the pres...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-14644 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukemia cell lines KG-1, U937 and THP-1 vs. normal human blood monocytes
Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor-suppressor genes. Genome wide methylation profiling of myeloid leukemia cell lines identified a large number of genes with aberrantly methylated CpG islands. Comparative ...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3280 | biostudies-arrayexpress
GenomicsThe enhancer and promoter landscape of human regulatory and conventional T cell subpopulations
CD4+CD25+FOXP3+ human regulatory T cells (Treg) are essential for self-tolerance and immune homeostasis. Here, we generated genome-wide maps of poised and active enhancer elements marked by histone H3 lysine 4 monomethylation and histone H3 lysine 27 acetylation for CD4+CD25highCD45RA+ naive and CD4...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-43119 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of differentially expressed regions between C57BL/6 and BALB/c in bone marrow derived macrophages
DNA-methylation is a vital epigenetic mark that participates in establishing and maintaining chromatin structures and in regulating gene transcription during mammalian development and cellular differentiation. Inter-individual differences in methylation patterns may represent a major source of pheno...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-14463 | biostudies-arrayexpress
GenomicsDynamic epigenetic enhancer signatures are predictive for key transcriptional regulators associated with cellular differentiation states
Cellular differentiation is orchestrated by lineage-specific transcription factors and associates with cell type-specific epigenetic signatures. Here, we utilized stage-specific, epigenetic "fingerprints" to deduce key transcriptional regulators of a cellular differentiation process. In th...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-31621 | biostudies-arrayexpress
Sort   by:  
 Page size