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ProteomicsDeubiquitinating enzymes in human macrophages after Francisella tularensis infection
Ubiquitination/deubiquitination belong to the most important regulatory mechanisms carried out through the attachment/removal of the ubiquitin molecule, respectively. The process is necessary not only to mark molecules for degradation, but also for example to the activation of signaling pathways lea...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043492 | Pride
Human Macrophage Francisella tularensis Lc-ms Host-pathogen 
ProteomicsThe identification of bacterial protein interaction partners pointed out to new intracellular functions of Francisella tularensis glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde-3-phopshate dehydrogenase (GAPDH) is well-known for its involvement in numerous non-metabolic processes inside the mammalian cells. Alternative functions of prokaryotic GAPDH are mainly deduced from its extracellular localization and the ability to bind to selected host proteins. Data...
ORGANISM(S): Francisella tularensis subsp. holarctica FSC200 Bacteria 
2020-08-31 | PXD019739 | Pride
Interaction partners Francisella tularensis 
ProteomicsFractionation of phosphopeptides using reversed phase microcolumn prior to LC-MS analysis
A protocol for an improved phosphopeptide identification in tryptically digested complex peptide samples is described. The common TiO2 based phoshopeptide enrichment is coupled to a simple peptide fractionation protocol with following LC-MS analysis of the obtained fractions and proteomic identifica...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD018663 | Pride
Phosphopeptide fractionation H1299 cell line Phosphorylation 
ProteomicsAmorphous TiO2 Nanotubes as Platform for Highly Selective Phos-phopeptide Enrichment
This work reports highly selective phosphopeptide enrichment using amorphous TiO2 nanotubes (TiO2NTs) and the same material decorated with superparamagnetic Fe3O4 nanoparticles (TiO2NTs@Fe3O4NPs). TiO2NTs and TiO2NTs@Fe3O4NPs materials were applied for phosphopeptide enrichment both from a simple pe...
ORGANISM(S): Homo sapiens (Human) 
2019-06-26 | PXD012749 | Pride
Phosphopeptide enrichment Nanotubes 
ProteomicsCross-species proteomic comparison of whole cell lysates, outer membrane vesicles and membrane fractions of Francisella tularensis subsp. tularensis versus subsp. holarctica
Secretion of outer membrane vesicles (OMV) presents an important phenomenon in Gram-negative bacteria and they play multiple roles in their lifestyle including virulence and host-pathogen interaction. Francisella tularensis secretes unusually shaped tubular OMV. We here present a proteomic compariso...
ORGANISM(S): Francisella tularensis Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. holarctica FSC200 
2021-02-08 | PXD022406 | Pride
Q-exactive Schus4 Outer membrane vesicles Fsc200 Cross-species proteomic comparison Francisella tularensis 
ProteomicsPhosphoproteome analysis of bone marrow-derived dendritic cells infected by Francisella tularensis – proteome dataset
Francisella tularensis is a highly infective Gram-negative bacterium, also known as the causative agent of tularemia. The disease is characterized by the delayed onset of the adaptive immune response which provides time for the bacterial replication. As an intracellular pathogen, Francisella prolife...
ORGANISM(S): Mus musculus (Mouse) Francisella tularensis subsp. holarctica FSC200 
2017-10-26 | PXD006759 | Pride
Francisella tularensis Bone marrow-derived dendritic cells Mapk signaling Phosphoproteome 
ProteomicsPhosphoproteome analysis of bone marrow-derived dendritic cells infected by Francisella tularensis
Francisella tularensis is a highly infective Gram-negative bacterium, also known as the causative agent of tularemia. The disease is characterized by the delayed onset of the adaptive immune response which provides time for the bacterial replication. As an intracellular pathogen, Francisella prolife...
ORGANISM(S): Mus musculus (Mouse) Francisella tularensis subsp. holarctica FSC200 
2017-10-26 | PXD005747 | Pride
Francisella tularensis Bone marrow-derived dendritic cells Mapk signaling Phosphoproteome 
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