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ProteomicsCdc48’s interactions play a role in the cellular oxidative response in an aging-dependent manner
The cellular redox status has long been linked to different cellular functions, including protein quality control (PQC) and aging. The prominent molecular machine Cdc48 (p97/VCP in mammals) is one of the key players involved in PQC, shuttling misfolded proteins to degradation. Through a range of N-t...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-28 | PXD045122 | Pride
Redox Yeast Aging 
ProteomicsTrypOx, a novel eukaryotic homologue of the redox-regulated chaperone Hsp33 in Trypanosoma brucei
In this study, we describe a novel eukaryotic homologue of Hsp33 in Trypanosoma brucei.Bioinformatics analysis of the Hsp33 family suggested that eukaryotic pathogens belonging to the kinetoplastids, such as Trypanosoma cruzi,Trypanosoma brucei spp, and leishmaniasis had persevered Hsp33 homologues...
ORGANISM(S): Trypanosoma brucei 
2020-07-28 | PXD018965 | Pride
Trypanosoma brucei Lc-ms/ms 
ProteomicsCOPPER INDUCES PROTEIN AGGREGATION, A TOXIC PROCESS COMPENSATED BY MOLECULAR CHAPERONES.
Copper is a powerful antimicrobial and antiviral agent, which has interest through several biomedical applications. Nevertheless, how copper induces the cellular damage is not fully understood. Two main mechanisms are claimed to be involved, i.e. Cu catalyzed reactive oxygen species production (ROS...
ORGANISM(S): Escherichia coli 
2022-02-10 | PXD019288 | Pride
Hsp33 Escherichia coli Molecular chaperone Copper Aggregation 
ProteomicsTemporal profiling of redox-dependent heterogeneity in single cells
Cellular redox status affects diverse cellular functions, including proliferation, protein homeostasis, and aging. Thus, individual differences in redox status can give rise to distinct sub-populations even among cells with identical genetic backgrounds. Here, we have created a novel methodology to ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-06-18 | PXD009443 | Pride
Yeast Redox 
ProteomicsCysteine Modification of Peptides and Proteins by Virtue of Highly Chemo-, Regio- and Stereoselective Hydrosulfuration of Ynamide
Chemoselective modification of peptides and proteins has wide applications in chemical biology and pharmaceutical development. A highly efficient chemo-, regio- and stereoselective hydrosulfuration of ynamide was developed by taking advantage of an unprecedented β-addition of the thiols. Importantly...
ORGANISM(S): Escherichia coli 
2024-09-25 | PXD038770 | Pride
Lc-ms/ms Iodoacetamide Modifications Ynamide Cysteine modification 
UnknownOverall survival with oral selinexor plus low-dose dexamethasone versus real-world therapy in triple-class-refractory multiple myeloma.
Not available
S-EPMC9175889 | biostudies-literature
UnknownRipretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial.
Not available
S-EPMC10878977 | biostudies-literature
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