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ProteomicsCdc48’s interactions play a role in the cellular oxidative response in an aging-dependent manner
The cellular redox status has long been linked to different cellular functions, including protein quality control (PQC) and aging. The prominent molecular machine Cdc48 (p97/VCP in mammals) is one of the key players involved in PQC, shuttling misfolded proteins to degradation. Through a range of N-t...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-28 | PXD045122 | Pride
Redox Yeast Aging 
ProteomicsTemporal profiling of redox-dependent heterogeneity in single cells
Cellular redox status affects diverse cellular functions, including proliferation, protein homeostasis, and aging. Thus, individual differences in redox status can give rise to distinct sub-populations even among cells with identical genetic backgrounds. Here, we have created a novel methodology to ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-06-18 | PXD009443 | Pride
Yeast Redox 
ProteomicsCysteine Modification of Peptides and Proteins by Virtue of Highly Chemo-, Regio- and Stereoselective Hydrosulfuration of Ynamide
Chemoselective modification of peptides and proteins has wide applications in chemical biology and pharmaceutical development. A highly efficient chemo-, regio- and stereoselective hydrosulfuration of ynamide was developed by taking advantage of an unprecedented β-addition of the thiols. Importantly...
ORGANISM(S): Escherichia coli 
2024-09-25 | PXD038770 | Pride
Lc-ms/ms Iodoacetamide Modifications Ynamide Cysteine modification 
UnknownOverall survival with oral selinexor plus low-dose dexamethasone versus real-world therapy in triple-class-refractory multiple myeloma.
Not available
S-EPMC9175889 | biostudies-literature
UnknownRipretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial.
Not available
S-EPMC10878977 | biostudies-literature
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