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ProteomicsNovel Eph receptor tyrosine kinase inhibitors block colorectal cancer cell growth
Despite advances, treatment of unresectable colorectal cancer remains a clinical challenge and the incidence of this malignancy is increasing in individuals below the age of fifty. Integrated genomic, transcriptomic, proteomic, and mechanistic studies identified the tyrosine kinase receptors EphB2 a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD031880 | Pride
Affinity pulldowns Kinobeads Lc-ms/ms 
UnknownAcute Angiotensin II Receptor Blockade Facilitates Parahippocampal Processing During Memory Encoding in High-Trait-Anxious Individuals.
Not available
S-EPMC10844816 | biostudies-literature
UnknownDynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory.
Not available
S-EPMC6449405 | biostudies-literature
UnknownA hypothetical astrocyte-microglia lactate shuttle derived from a 1H NMR metabolomics analysis of cerebrospinal fluid from a cohort of South African children with tuberculous meningitis.
Not available
S-EPMC4475545 | biostudies-literature
ProteomicsChemoproteomic selectivity profiling of PIKK and PI3K kinase inhibitors
"Here, we report the development of a novel version of Kinobeads that extends kinome coverage to PIKK and PI3K kinases. This is achieved by inclusion of two affinity probes derived from the clinical PI3K/MTOR inhibitors Omipalisib and BGT226. The new affinity matrix was used to profile 13 clinical a...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD011719 | Pride
Chemoproteomics" "kinobeads Drug profiling 
UnknownLXRα Regulates oxLDL-Induced Trained Immunity in Macrophages.
Not available
S-EPMC9181299 | biostudies-literature
UnknownHuman perceptual learning is delayed by the N-methyl-D-aspartate receptor partial agonist D-cycloserine.
Not available
S-EPMC7924109 | biostudies-literature
ProteomicsAcetylation and phosphorylation changes to cardiac proteins in experimental HFpEF due to metabolic risk reveal targets for treatment
Aims: Despite the high prevalence of heart failure with preserved ejection fraction (HFpEF), the pathomechanisms remain elusive and specific therapy is lacking. Disease-causing factors include metabolic risk, notably obesity. However, proteomic changes in HFpEF are poorly understood, hampering thera...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-12 | PXD036259 | Pride
Diastolic dysfunction  proteomics  obesity  meta-inflammation  stiffness 
UnknownClinical Course of Infection and Cross-Species Detection of Equine Parvovirus-Hepatitis.
Not available
S-EPMC8402690 | biostudies-literature
UnknownImpact of diabetes on outcome in critical limb ischemia with tissue loss: a large-scaled routine data analysis.
Not available
S-EPMC5379505 | biostudies-literature
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