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ProteomicsLis1 in human hippocampus organoids
Lysate analysis of WT or Lis1-mutant human hippocampus organoids
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD040911 | Pride
Organoids Hippocampus Human Lis1 Lc-ms/ms 
ProteomicsLis1 in human cortical organoids
Lysate analysis of WT or Lis1-mutant human cortical organoids
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD040813 | Pride
Organoids Cortex Lis1 
ProteomicsDysregulated Extracellular Matrix and Increased Stiffness in Lissencephaly Brain Organoid Models
LIS1 mutations are known to cause lissencephaly, a neurological disorder characterized by the absence of cerebral cortical convolutions. Here we show that brain organoids with LIS1 mutations exhibit increased expression of extracellular matrix (ECM) proteins, which are less organized. The mechanical...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD049178 | Pride
Extracellular matrix Brain Organoid 
ProteomicsLIS1 RNA binding orchestartes the mechanosensitive properties of embryonic stem cells in AGO2 dependent and independent ways.
LIS1 immunoprecipitation in nuclear and cytoplasmic fractions of LIS1 Floxed/-, OE and WT embryonic stem cells. To identify AGO2 dependent and independent interactions LIS1 was immunoprecipitated in AGO1-4 knockout and doxycycline induced AGO2 mouse embryonic stem cells.
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD033150 | Pride
Oe Dox.ago2 Ago1-4 ko Nuclear and cytoplasmic fractions Flox/- Wt Mouse embyonic stem cells Lis1 ip 
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