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Transcriptomicsin-vitro differentiated midbrain dopaminergic neurons from isogenic human induced pluripotent stem cells
We have generated isogenic induced pluripotent stem cell lines by reprogramming human fibroblasts from patients carrying the LRRK2 G2019S mutation with subsequent zinc finger nuclease - mediated targeted correction of the diseased allele. These iPS cell lines were differentiated for 30 days using a ...
ORGANISM(S): Homo sapiens 
2013-03-07 | E-GEOD-43364 | biostudies-arrayexpress
TranscriptomicsRNA-seq of five Populus x canescens (Grey poplar) organs/tissues during periodic or chronic drought-heat stress treatment and after recovery in comparison to untreated controls
Simulating predicted future climate conditions, stress response and stress-related memory after one week of recovery were transcriptionally characterised in young and old leaves, phloem-bark, developing xylem and roots of 3-month-old Grey poplar plants that had undergone three weeks of stress or wer...
ORGANISM(S): Populus tremula x Populus alba 
2019-01-11 | E-MTAB-6121 | biostudies-arrayexpress
TranscriptomicsHuman adult germline stem cells in question
Conrad et al. Nature 456, 344–349 (2008) have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression ...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-17772 | biostudies-arrayexpress
UnknownDataset of a retrospective multicenter cohort study on characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis.
Not available
S-EPMC9679487 | biostudies-literature
TranscriptomicsDual RNA-seq – Comparative RNA-seq (in vitro medium shift experiment)
Bacteria possess many small noncoding RNAs whose regulatory roles in pathogenesis are little understood due to a paucity of macroscopic phenotypes in standard virulence assays. Here, we use a novel Dual RNA-seq approach for a single-step simultaneous RNA profiling in both pathogen and host to reveal...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2015-12-11 | E-GEOD-67949 | biostudies-arrayexpress
TranscriptomicsDual RNA-seq of diverse human, mouse and pig cell-types infected with various Salmonella strains
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): mixed sample: human cell line AGS and Salmonella Typhimurium SL1344 
2015-12-11 | E-GEOD-60144 | biostudies-arrayexpress
TranscriptomicsGeneration of Induced Pluripotent Stem Cells from Human Testis Biopsy Derived Fibroblastic Cells
Although reported more than once, the generation of pluripotent stem cell populations from human testis remains questionable. We recently showed that the so - called human adult germline stem cells (haGSCs), which were claimed to be pluripotent, showed a gene expression profile comparable to human f...
ORGANISM(S): Homo sapiens 
2011-04-02 | E-GEOD-21179 | biostudies-arrayexpress
GenomicsComprehensive genomic profiles of small cell lung cancer
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. We found bi-allelic inactivation of TP53 and RB1 in nearly all the tumors analyzed, sometimes by complex genomic rearrangements. Two tumors with wild-type RB1 had evidence of chromothripsis leadi...
EGAS00001000925 | EGA
TranscriptomicsOrigin-dependent neural cell identities in differentiated human iPS cells in vitro and after transplantation into the rodent brain
The differentiation capability of induced pluripotent stem cells (iPSCs) towards certain cell types for disease modelling and drug screening assays might be influenced by their somatic cell of origin. Here, we have compared the neural induction of human iPSCs generated from either fetal neural stem ...
ORGANISM(S): Homo sapiens 
2014-09-12 | E-GEOD-55107 | biostudies-arrayexpress
GenomicsSCLC_SNP_6.0 - samples
SNP 6.0 arrays of small cell lung cancer
EGAD00010000558 | EGA
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